3O23
Human unphosphorylated IGF1-R Kinase domain in complex with an hydantoin inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Insulin-like growth factor 1 receptor | polymer | 305 | 34794.9 | 1 | UniProt (P08069) Pfam (PF07714) | Homo sapiens (human) | Insulin-like growth factor I receptor, IGF-I receptor, Insulin-like growth factor 1 receptor alpha chain, Insulin-like growth factor 1 receptor beta chain |
| 2 | B (A) | (5S)-5-methyl-1-(quinolin-4-ylmethyl)-3-{4-[(trifluoromethyl)sulfonyl]phenyl}imidazolidine-2,4-dione | non-polymer | 463.4 | 1 | Chemie (MQY) | |||
| 3 | C (A) | water | water | 18.0 | 85 | Chemie (HOH) |
Sequence modifications
A: 982 - 1286 (UniProt: P08069)
| PDB | External Database | Details |
|---|---|---|
| Phe 987 | Tyr 987 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34794.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 463.4 | |
| All* | Total formula weight | 35258.3 |
