3NYJ

Crystal Structure Analysis of APP E2 domain

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Amyloid beta A4 protein	polymer	207	24770.7	1	UniProt (P05067) Pfam (PF12925) In PDB	Homo sapiens (human)	Alzheimer disease amyloid protein, ABPP, APPI, APP, PreA4, Cerebral vascular amyloid peptide, CVAP, Protease nexin-II, PN-II, N-APP, Soluble APP-alpha, S-APP-alpha, Soluble APP-beta, S-APP-beta, C99, Beta-amyloid protein 42, Beta-APP42, Beta-amyloid protein 40, Beta-APP40, C83, P3(42), P3(40), C80, Gamma-secretase C-terminal fragment 59, Gamma-CTF(59), Amyloid intracellular domain 59, AICD-59, AID(59), Gamma-secretase C-terminal fragment 57, Gamma-CTF(57), Amyloid intracellular domain 57, AICD-57, AID(57), Gamma-secretase C-terminal fragment 50, Gamma-CTF(50), Amyloid intracellular domain 50, AICD-50, AID(50), C31
2	A	OSMIUM ION	non-polymer		190.2	1	Chemie (OS)
3		water	water		18.0	36	Chemie (HOH)

Sequence modifications

A: 346 - 548 (UniProt: P05067)

PDB	External Database	Details
Gly 342	-	EXPRESSION TAG
Ser 343	-	EXPRESSION TAG
His 344	-	EXPRESSION TAG
Mse 345	-	EXPRESSION TAG

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	24770.7
Non-Polymers*	Number of molecules	1
	Total formula weight	190.2
All*	Total formula weight	24961.0

*Water molecules are not included.