3NU9
Crystal Structure of HIV-1 Protease Mutant I84V with Antiviral Drug Amprenavir
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Protease | polymer | 99 | 10726.6 | 2 | UniProt (P03366) | Human immunodeficiency virus 1 | |
| 2 | C (A) | {3-[(4-AMINO-BENZENESULFONYL)-ISOBUTYL-AMINO]-1-BENZYL-2-HYDROXY-PROPYL}-CARBAMIC ACID TETRAHYDRO-FURAN-3-YL ESTER | non-polymer | 505.6 | 1 | Chemie (478) PubChem (2177) PubChem (22868212) PubChem (65016) PubChem (44342222) PubChem (59964701) PubChem (68088939) PubChem (68336859) PubChem (68164690) PubChem (441385) PubChem (92209736) PubChem (124638074) PubChem (10885665) PubChem (11168069) PubChem (6540587) PubChem (9898472) PubChem (141823677) | |||
| 3 | AA, BA, CA, D, DA... (B, A) | IODIDE ION | non-polymer | 126.9 | 30 | Chemie (IOD) PubChem (30165) | |||
| 4 | HA, IA (A, B) | water | water | 18.0 | 84 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 99 (UniProt: P03366)
| PDB | External Database | Details |
|---|---|---|
| Lys 7 | Gln 507 | engineered mutation |
| Ile 33 | Leu 533 | engineered mutation |
| Ile 63 | Leu 563 | engineered mutation |
| Ala 67 | Cys 567 | engineered mutation |
| Val 84 | Ile 584 | engineered mutation |
| Ala 95 | Cys 595 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 21453.3 | |
| Non-Polymers* | Number of molecules | 31 |
| Total formula weight | 4312.7 | |
| All* | Total formula weight | 25766.0 |
