3NCE
A mutant human Prolactin receptor antagonist H27A in complex with the mutant extracellular domain H188A of the human prolactin receptor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Prolactin | polymer | 186 | 21724.8 | 1 | UniProt (P01236) Pfam (PF00103) | Homo sapiens (human) | PRL |
| 2 | B (B) | Prolactin receptor | polymer | 210 | 24378.8 | 1 | UniProt (P16471) Pfam (PF09067) | Homo sapiens (human) | PRL-R |
| 3 | C, F, G, I, J (A, B) | SODIUM ION | non-polymer | 23.0 | 5 | Chemie (NA) | |||
| 4 | D, E (A) | CARBONATE ION | non-polymer | 60.0 | 2 | Chemie (CO3) | |||
| 5 | H (B) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 6 | K, L (A, B) | water | water | 18.0 | 452 | Chemie (HOH) |
Sequence modifications
A: 15 - 199 (UniProt: P01236)
B: 2 - 210 (UniProt: P16471)
| PDB | External Database | Details |
|---|---|---|
| Met 14 | - | initiating methionine |
| Ala 27 | His 55 | engineered mutation |
| Arg 129 | Gly 157 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Met 1 | - | initiating methionine |
| Ala 188 | His 212 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 46103.6 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 270.4 | |
| All* | Total formula weight | 46374.0 |
