3NCE
A mutant human Prolactin receptor antagonist H27A in complex with the mutant extracellular domain H188A of the human prolactin receptor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001937 | biological_process | negative regulation of endothelial cell proliferation |
| A | 0005148 | molecular_function | prolactin receptor binding |
| A | 0005179 | molecular_function | hormone activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0007166 | biological_process | cell surface receptor signaling pathway |
| A | 0007565 | biological_process | female pregnancy |
| A | 0007595 | biological_process | lactation |
| A | 0008284 | biological_process | positive regulation of cell population proliferation |
| A | 0016525 | biological_process | negative regulation of angiogenesis |
| A | 0030879 | biological_process | mammary gland development |
| A | 0031667 | biological_process | response to nutrient levels |
| A | 0031904 | cellular_component | endosome lumen |
| A | 0038161 | biological_process | prolactin signaling pathway |
| A | 0043123 | biological_process | positive regulation of canonical NF-kappaB signal transduction |
| A | 0046427 | biological_process | positive regulation of receptor signaling pathway via JAK-STAT |
| A | 1902895 | biological_process | positive regulation of miRNA transcription |
| A | 1903489 | biological_process | positive regulation of lactation |
| B | 0004896 | molecular_function | cytokine receptor activity |
| B | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE NA A 5 |
| Chain | Residue |
| A | ARG177 |
| B | THR98 |
| B | HOH352 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CO3 A 6 |
| Chain | Residue |
| A | ARG16 |
| A | ARG103 |
| A | HIS195 |
| A | HOH240 |
| A | HOH336 |
| site_id | AC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CO3 A 7 |
| Chain | Residue |
| A | ARG21 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA B 211 |
| Chain | Residue |
| B | PRO15 |
| B | THR19 |
| B | PHE20 |
| B | THR21 |
| B | HIS63 |
| B | HOH429 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA B 212 |
| Chain | Residue |
| A | HOH249 |
| B | LYS66 |
| B | THR69 |
| B | HOH355 |
| B | HOH431 |
| site_id | AC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL B 213 |
| Chain | Residue |
| B | TRP191 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA B 214 |
| Chain | Residue |
| B | TYR54 |
| B | GLY58 |
| B | ASN60 |
| B | SER61 |
| B | HOH293 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA B 215 |
| Chain | Residue |
| B | HOH321 |
| B | HOH361 |
| B | HOH408 |
| B | HOH415 |
| B | HOH418 |
| B | HOH420 |
Functional Information from PROSITE/UniProt
| site_id | PS00266 |
| Number of Residues | 34 |
| Details | SOMATOTROPIN_1 Somatotropin, prolactin and related hormones signature 1. ChTssLaTPedkeqAqqmnqkdFlslivsIlrSW |
| Chain | Residue | Details |
| A | CYS58-TRP91 |
| site_id | PS00338 |
| Number of Residues | 18 |
| Details | SOMATOTROPIN_2 Somatotropin, prolactin and related hormones signature 2. CLRrDShKIDnYlkLlkC |
| Chain | Residue | Details |
| A | CYS174-CYS191 |
| site_id | PS01352 |
| Number of Residues | 78 |
| Details | HEMATOPO_REC_L_F1 Long hematopoietin receptor, single chain family signature. LwIkWspptlidlktgwftllYEIrlkpekaaeweihfagqqtefkils..LhpgqkylvqvRcKpdagy....WsaWspatfI |
| Chain | Residue | Details |
| B | LEU123-ILE200 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 209 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| B | MET1-ASP210 | |
| A | SER34 | |
| A | SER90 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: |
| Chain | Residue | Details |
| B | ASP187 | |
| B | ALA188 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| B | ASN35 | |
| B | ASN80 | |
| B | ASN209 |
