3NCC
A human Prolactin receptor antagonist in complex with the mutant extracellular domain H188A of the human prolactin receptor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Prolactin | polymer | 186 | 21791.9 | 1 | UniProt (P01236) Pfam (PF00103) | Homo sapiens (human) | PRL |
| 2 | B (B) | Prolactin receptor | polymer | 210 | 24378.8 | 1 | UniProt (P16471) Pfam (PF09067) | Homo sapiens (human) | PRL-R |
| 3 | C, D, F (B) | SODIUM ION | non-polymer | 23.0 | 3 | Chemie (NA) | |||
| 4 | E (B) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 5 | G (B) | CARBONATE ION | non-polymer | 60.0 | 1 | Chemie (CO3) | |||
| 6 | H, I (A, B) | water | water | 18.0 | 229 | Chemie (HOH) |
Sequence modifications
A: 15 - 199 (UniProt: P01236)
B: 2 - 210 (UniProt: P16471)
| PDB | External Database | Details |
|---|---|---|
| Met 14 | - | initiating methionine |
| Arg 129 | Gly 157 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Met 1 | - | initiating methionine |
| Ala 188 | His 212 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 46170.7 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 164.4 | |
| All* | Total formula weight | 46335.1 |
