3NCC
A human Prolactin receptor antagonist in complex with the mutant extracellular domain H188A of the human prolactin receptor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001937 | biological_process | negative regulation of endothelial cell proliferation |
| A | 0005148 | molecular_function | prolactin receptor binding |
| A | 0005179 | molecular_function | hormone activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0007166 | biological_process | cell surface receptor signaling pathway |
| A | 0007565 | biological_process | female pregnancy |
| A | 0007595 | biological_process | lactation |
| A | 0016525 | biological_process | negative regulation of angiogenesis |
| A | 0030879 | biological_process | mammary gland development |
| A | 0031667 | biological_process | response to nutrient levels |
| A | 0031904 | cellular_component | endosome lumen |
| A | 0031982 | cellular_component | vesicle |
| A | 0038161 | biological_process | prolactin signaling pathway |
| A | 0043123 | biological_process | positive regulation of canonical NF-kappaB signal transduction |
| A | 0046427 | biological_process | positive regulation of receptor signaling pathway via JAK-STAT |
| A | 1902895 | biological_process | positive regulation of miRNA transcription |
| A | 1903489 | biological_process | positive regulation of lactation |
| B | 0004896 | molecular_function | cytokine receptor activity |
| B | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA B 211 |
| Chain | Residue |
| B | PRO15 |
| B | THR19 |
| B | PHE20 |
| B | THR21 |
| B | HIS63 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA B 212 |
| Chain | Residue |
| B | THR69 |
| B | HOH331 |
| A | ASP68 |
| A | HOH238 |
| A | HOH244 |
| B | LYS66 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL B 213 |
| Chain | Residue |
| B | TYR190 |
| B | TRP191 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NA B 214 |
| Chain | Residue |
| B | TYR54 |
| B | GLY58 |
| B | ASN60 |
| B | SER61 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CO3 B 215 |
| Chain | Residue |
| B | LYS11 |
| B | TRP23 |
| B | HOH337 |
Functional Information from PROSITE/UniProt
| site_id | PS00266 |
| Number of Residues | 34 |
| Details | SOMATOTROPIN_1 Somatotropin, prolactin and related hormones signature 1. ChTssLaTPedkeqAqqmnqkdFlslivsIlrSW |
| Chain | Residue | Details |
| A | CYS58-TRP91 |
| site_id | PS00338 |
| Number of Residues | 18 |
| Details | SOMATOTROPIN_2 Somatotropin, prolactin and related hormones signature 2. CLRrDShKIDnYlkLlkC |
| Chain | Residue | Details |
| A | CYS174-CYS191 |
| site_id | PS01352 |
| Number of Residues | 78 |
| Details | HEMATOPO_REC_L_F1 Long hematopoietin receptor, single chain family signature. LwIkWspptlidlktgwftllYEIrlkpekaaeweihfagqqtefkils..LhpgqkylvqvRcKpdagy....WsaWspatfI |
| Chain | Residue | Details |
| B | LEU123-ILE200 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P01239","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"15687336","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine; partial"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 101 |
| Details | Domain: {"description":"Fibronectin type-III 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00316","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 100 |
| Details | Domain: {"description":"Fibronectin type-III 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00316","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Motif: {"description":"WSXWS motif"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
