3N84
Crystal Structure of the Grb2 SH2 Domain in Complex with a 23-Membered Macrocyclic Ligand Having the Sequence pYVNVP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Growth factor receptor-bound protein 2 | polymer | 112 | 13060.9 | 6 | UniProt (P62993) Pfam (PF00017) | Homo sapiens (human) | Adapter protein GRB2, Protein Ash, SH2/SH3 adapter GRB2 |
| 2 | G, H, I, J, K... (G, H, I, J, K...) | 23-membered peptide-like macrocyclic ligand | polymer | 6 | 797.8 | 6 | |||
| 3 | M, N (A) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 4 | O, Q, R, S, T... (B, D, E, F, K) | GLYCEROL | non-polymer | 92.1 | 7 | Chemie (GOL) | |||
| 5 | P (C) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 6 | AA, BA, CA, DA, EA... (E, F, G, H, I...) | water | water | 18.0 | 728 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F: 53 - 163 (UniProt: P62993)
| PDB | External Database | Details |
|---|---|---|
| Met 52 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 83152.1 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 739.9 | |
| All* | Total formula weight | 83892.0 |
