Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL A 9 |
| Chain | Residue |
| A | TRP121 |
| A | VAL122 |
| A | VAL123 |
| A | ARG142 |
| A | HOH326 |
| site_id | AC2 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL A 10 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL B 6 |
| Chain | Residue |
| B | HOH716 |
| D | LYS69 |
| B | GLU54 |
| B | MET55 |
| B | HOH247 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG C 8 |
| Chain | Residue |
| C | TRP121 |
| C | VAL122 |
| C | VAL123 |
| C | ARG142 |
| C | HOH727 |
| site_id | AC5 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GOL D 3 |
| Chain | Residue |
| D | ASP80 |
| D | GLY102 |
| D | HOH164 |
| D | HOH183 |
| E | HOH47 |
| E | ARG112 |
| E | ASP113 |
| E | PHE119 |
| E | HOH179 |
| E | HOH521 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL E 1 |
| Chain | Residue |
| A | PHE95 |
| A | ARG112 |
| A | TYR118 |
| A | HOH214 |
| E | GLY93 |
| E | PHE95 |
| E | VAL110 |
| E | ARG112 |
| E | HOH415 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL F 2 |
| Chain | Residue |
| B | ASP80 |
| B | GLY102 |
| B | HOH170 |
| B | HOH200 |
| F | HOH48 |
| F | ARG112 |
| F | ASP113 |
| F | PHE119 |
| site_id | AC8 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL F 4 |
| Chain | Residue |
| C | PHE95 |
| C | ARG112 |
| C | TYR118 |
| C | HOH483 |
| F | GLY93 |
| F | PHE95 |
| F | VAL110 |
| F | ARG112 |
| F | HOH538 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL F 7 |
| Chain | Residue |
| E | HOH189 |
| F | ARG67 |
| F | SER90 |
| F | HOH282 |
| F | HOH288 |
| L | PTR1 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL K 7 |
| Chain | Residue |
| E | ARG67 |
| E | SER90 |
| E | HOH343 |
| F | HOH301 |
| K | PTR1 |
| K | HOH335 |
| site_id | BC2 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR CHAIN G OF 23-MEMBERED PEPTIDE-LIKE MACROCYCLIC LIGAND |
| Chain | Residue |
| A | HOH42 |
| A | ARG67 |
| A | ARG86 |
| A | SER88 |
| A | SER90 |
| A | SER96 |
| A | GLN106 |
| A | HIS107 |
| A | PHE108 |
| A | LYS109 |
| A | LEU120 |
| A | TRP121 |
| A | ASN143 |
| A | HOH165 |
| F | GLN144 |
| G | HOH67 |
| G | HOH82 |
| G | HOH114 |
| G | HOH226 |
| G | HOH227 |
| G | HOH613 |
| L | VAL2 |
| site_id | BC3 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR CHAIN H OF 23-MEMBERED PEPTIDE-LIKE MACROCYCLIC LIGAND |
| Chain | Residue |
| B | LEU120 |
| B | TRP121 |
| B | ASN143 |
| E | MET52 |
| H | HOH84 |
| H | HOH94 |
| H | HOH256 |
| H | HOH294 |
| H | HOH546 |
| L | PRO5 |
| A | GLN144 |
| A | GLN162 |
| A | HOH179 |
| A | HOH457 |
| B | ARG67 |
| B | ARG86 |
| B | SER88 |
| B | SER90 |
| B | SER96 |
| B | GLN106 |
| B | HIS107 |
| B | PHE108 |
| B | LYS109 |
| site_id | BC4 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR CHAIN I OF 23-MEMBERED PEPTIDE-LIKE MACROCYCLIC LIGAND |
| Chain | Residue |
| C | HOH32 |
| C | ARG67 |
| C | ARG86 |
| C | SER88 |
| C | SER90 |
| C | SER96 |
| C | GLN106 |
| C | HIS107 |
| C | PHE108 |
| C | LYS109 |
| C | LEU120 |
| C | TRP121 |
| C | SER141 |
| E | GLN144 |
| E | HOH177 |
| I | HOH7 |
| I | HOH134 |
| I | HOH151 |
| I | HOH159 |
| I | HOH185 |
| I | HOH400 |
| site_id | BC5 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR CHAIN J OF 23-MEMBERED PEPTIDE-LIKE MACROCYCLIC LIGAND |
| Chain | Residue |
| C | GLN144 |
| D | ARG67 |
| D | ARG86 |
| D | SER88 |
| D | SER90 |
| D | SER96 |
| D | HIS107 |
| D | PHE108 |
| D | LYS109 |
| D | LEU120 |
| D | TRP121 |
| D | ASN143 |
| D | HOH410 |
| J | HOH41 |
| J | HOH87 |
| J | HOH138 |
| J | HOH396 |
| J | HOH406 |
| J | HOH428 |
| J | HOH430 |
| K | PRO5 |
| site_id | BC6 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR CHAIN K OF 23-MEMBERED PEPTIDE-LIKE MACROCYCLIC LIGAND |
| Chain | Residue |
| D | GLN144 |
| D | HOH188 |
| E | HOH8 |
| E | ARG67 |
| E | ARG86 |
| E | SER88 |
| E | SER90 |
| E | SER96 |
| E | GLN106 |
| E | HIS107 |
| E | PHE108 |
| E | LYS109 |
| E | LEU120 |
| E | TRP121 |
| E | HOH631 |
| E | HOH691 |
| J | VAL2 |
| K | GOL7 |
| K | HOH131 |
| K | HOH512 |
| K | HOH514 |
| K | HOH606 |
| site_id | BC7 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR CHAIN L OF 23-MEMBERED PEPTIDE-LIKE MACROCYCLIC LIGAND |
| Chain | Residue |
| B | GLN106 |
| B | GLN144 |
| B | HOH168 |
| B | HOH557 |
| B | HOH661 |
| F | GOL7 |
| F | HOH28 |
| F | ARG67 |
| F | ARG86 |
| F | SER88 |
| F | SER90 |
| F | SER96 |
| F | GLN106 |
| F | HIS107 |
| F | PHE108 |
| F | LYS109 |
| F | LEU120 |
| F | TRP121 |
| F | ASN143 |
| F | HOH185 |
| G | PRO5 |
| H | VAL2 |
| H | HOH550 |
| L | HOH152 |
| L | HOH292 |
