3MZS
Crystal Structure of Cytochrome P450 CYP11A1 in complex with 22-hydroxy-cholesterol
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Cholesterol side-chain cleavage enzyme | polymer | 486 | 57116.8 | 4 | UniProt (P00189) Pfam (PF00067) | Bos taurus (bovine cow domestic cattle domestic cow) | Cytochrome P450 11A1, CYPXIA1, Cytochrome P450(scc), Cholesterol desmolase |
| 2 | E, H, K, N (A, B, C, D) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 4 | Chemie (HEM) | |||
| 3 | F, I, L, O (A, B, C, D) | (3alpha,8alpha,22R)-cholest-5-ene-3,22-diol | non-polymer | 402.7 | 4 | Chemie (HC9) | |||
| 4 | G, J, M, P (A, B, C, D) | ISOPROPYL ALCOHOL | non-polymer | 60.1 | 4 | Chemie (IPA) | |||
| 5 | Q, R, S, T (A, B, C, D) | water | water | 18.0 | 92 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 3 - 482 (UniProt: P00189)
| PDB | External Database | Details |
|---|---|---|
| Met 1 | - | expression tag |
| Ala 2 | - | expression tag |
| His 483 | - | expression tag |
| His 484 | - | expression tag |
| His 485 | - | expression tag |
| His 486 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 228467.3 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 4316.9 | |
| All* | Total formula weight | 232784.2 |
