3MSS
Abl kinase in complex with imatinib and fragment (FRAG2) in the myristate site
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Tyrosine-protein kinase ABL1 | polymer | 293 | 33743.5 | 4 | UniProt (P00520) Pfam (PF07714) | Mus musculus (mouse) | Abelson murine leukemia viral oncogene homolog 1, Proto-oncogene c-Abl, p150 |
| 2 | E, G, I, K (A, B, C, D) | 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE | non-polymer | 493.6 | 4 | Chemie (STI) | |||
| 3 | F, H, J, L (A, B, C, D) | O-benzyl-N-methyl-L-tyrosinamide | non-polymer | 284.4 | 4 | Chemie (MS7) | |||
| 4 | M, N, O, P (A, B, C, D) | water | water | 18.0 | 727 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 229 - 515 (UniProt: P00520)
| PDB | External Database | Details |
|---|---|---|
| Gly 223 | - | expression tag |
| Ala 224 | - | expression tag |
| Met 225 | - | expression tag |
| Asp 226 | - | expression tag |
| Pro 227 | - | expression tag |
| Ser 228 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 134974.1 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 3111.8 | |
| All* | Total formula weight | 138085.9 |
