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3MSS

Abl kinase in complex with imatinib and fragment (FRAG2) in the myristate site

Functional Information from GO Data
ChainGOidnamespacecontents
A0004672molecular_functionprotein kinase activity
A0004713molecular_functionprotein tyrosine kinase activity
A0005524molecular_functionATP binding
A0006468biological_processprotein phosphorylation
B0004672molecular_functionprotein kinase activity
B0004713molecular_functionprotein tyrosine kinase activity
B0005524molecular_functionATP binding
B0006468biological_processprotein phosphorylation
C0004672molecular_functionprotein kinase activity
C0004713molecular_functionprotein tyrosine kinase activity
C0005524molecular_functionATP binding
C0006468biological_processprotein phosphorylation
D0004672molecular_functionprotein kinase activity
D0004713molecular_functionprotein tyrosine kinase activity
D0005524molecular_functionATP binding
D0006468biological_processprotein phosphorylation
Functional Information from PDB Data
site_idAC1
Number of Residues16
DetailsBINDING SITE FOR RESIDUE STI A 1
ChainResidue
AHOH93
APHE317
AMET318
AILE360
AHIS361
AALA380
AASP381
APHE382
ALEU248
AALA269
ALYS271
AGLU286
AMET290
AVAL299
AILE313
ATHR315

site_idAC2
Number of Residues17
DetailsBINDING SITE FOR RESIDUE STI B 1
ChainResidue
BHOH65
BLEU248
BALA269
BLYS271
BGLU286
BMET290
BILE293
BVAL299
BILE313
BTHR315
BPHE317
BMET318
BILE360
BHIS361
BALA380
BASP381
BPHE382

site_idAC3
Number of Residues17
DetailsBINDING SITE FOR RESIDUE STI C 1
ChainResidue
CHOH48
CLEU248
CALA269
CLYS271
CGLU286
CMET290
CILE293
CVAL299
CILE313
CTHR315
CPHE317
CMET318
CILE360
CHIS361
CALA380
CASP381
CPHE382

site_idAC4
Number of Residues17
DetailsBINDING SITE FOR RESIDUE STI D 1
ChainResidue
DHOH86
DALA269
DLYS271
DGLU286
DVAL289
DMET290
DILE293
DVAL299
DILE313
DTHR315
DPHE317
DMET318
DILE360
DHIS361
DALA380
DASP381
DPHE382

site_idAC5
Number of Residues7
DetailsBINDING SITE FOR RESIDUE MS7 A 516
ChainResidue
AALA337
ALEU341
AALA433
APRO465
AVAL468
AHOH607
AHOH690

site_idAC6
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MS7 B 516
ChainResidue
BALA337
BLEU341
BALA433
BPRO465
BHOH546

site_idAC7
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MS7 C 516
ChainResidue
CALA337
CLEU341
CALA433
CPRO465
CVAL468
CHOH577

site_idAC8
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MS7 D 516
ChainResidue
DALA337
DLEU341
DALA433
DPRO465
DHOH602

Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues24
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGGGQYGEVYeGvwkkyslt..........VAVK
ChainResidueDetails
ALEU248-LYS271

site_idPS00109
Number of Residues13
DetailsPROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. FIHrDLAARNCLV
ChainResidueDetails
APHE359-VAL371

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028
ChainResidueDetails
AASP363
BASP363
CASP363
DASP363

site_idSWS_FT_FI2
Number of Residues8
DetailsBINDING: BINDING => ECO:0000305
ChainResidueDetails
ALEU248
AGLU316
BLEU248
BGLU316
CLEU248
CGLU316
DLEU248
DGLU316

site_idSWS_FT_FI3
Number of Residues4
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
ChainResidueDetails
ALYS271
BLYS271
CLYS271
DLYS271

site_idSWS_FT_FI4
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P42684
ChainResidueDetails
ASER229
BSER229
CSER229
DSER229

site_idSWS_FT_FI5
Number of Residues12
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P00519
ChainResidueDetails
ATYR253
DTYR253
DTYR257
DTYR413
ATYR257
ATYR413
BTYR253
BTYR257
BTYR413
CTYR253
CTYR257
CTYR413

site_idSWS_FT_FI6
Number of Residues4
DetailsMOD_RES: Phosphotyrosine; by autocatalysis and SRC-type Tyr-kinases => ECO:0000269|PubMed:10988075, ECO:0000269|PubMed:12748290
ChainResidueDetails
ATYR393
BTYR393
CTYR393
DTYR393

site_idSWS_FT_FI7
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:9109492
ChainResidueDetails
ASER446
BSER446
CSER446
DSER446

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PDB entries from 2024-08-07

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