3MRP

Crystal Structure of MHC class I HLA-A2 molecule complexed with Melan-A MART1 decapeptide variant

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	HLA class I histocompatibility antigen, A-2 alpha chain	polymer	293	34008.7	1	UniProt (P01892) Pfam (PF00129) Pfam (PF07654) UniProt (by SIFTS) (P04439)	Homo sapiens (human)	MHC class I antigen A*2
2	B (B)	Beta-2-microglobulin	polymer	100	11879.4	1	UniProt (P61769) Pfam (PF07654)	Homo sapiens (human)	Beta-2-microglobulin form pI 5.3
3	C (P)	10-meric peptide from Melanoma antigen recognized by T-cells 1	polymer	10	986.1	1	UniProt (Q16655)	Homo sapiens
4	D, E, F (A, B, P)	water	water		18.0	131	Chemie (HOH)

Sequence modifications

A: 1 - 276 (UniProt: P01892)

PDB	External Database	Details
Val 245	Ala 269	engineered mutation
Gly 277	-	expression tag
Ser 278	-	expression tag
Leu 279	-	expression tag
His 280	-	expression tag
His 281	-	expression tag
Ile 282	-	expression tag
Leu 283	-	expression tag
Asp 284	-	expression tag
Ala 285	-	expression tag
Gln 286	-	expression tag
Lys 287	-	expression tag
Met 288	-	expression tag
Val 289	-	expression tag
Trp 290	-	expression tag
Asn 291	-	expression tag
His 292	-	expression tag
Arg 293	-	expression tag

B: 1 - 99 (UniProt: P61769)

PDB	External Database	Details
Met 0	-	expression tag

P: 1 - 10 (UniProt: Q16655)

PDB	External Database	Details
Leu 2	Ala 27	SEE REMARK 999
Leu 5	Ile 30	engineered mutation
Asn 8	Leu 33	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	46874.2
All*	Total formula weight	46874.2

*Water molecules are not included.