3MRP
Crystal Structure of MHC class I HLA-A2 molecule complexed with Melan-A MART1 decapeptide variant
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | HLA class I histocompatibility antigen, A-2 alpha chain | polymer | 293 | 34008.7 | 1 | UniProt (P01892) Pfam (PF00129) Pfam (PF07654) UniProt (by SIFTS) (P04439) In PDB | Homo sapiens (human) | MHC class I antigen A*2 |
2 | B | Beta-2-microglobulin | polymer | 100 | 11879.4 | 1 | UniProt (P61769) Pfam (PF07654) In PDB | Homo sapiens (human) | Beta-2-microglobulin form pI 5.3 |
3 | P | 10-meric peptide from Melanoma antigen recognized by T-cells 1 | polymer | 10 | 986.1 | 1 | UniProt (Q16655) In PDB | Homo sapiens | |
4 | water | water | 18.0 | 131 | Chemie (HOH) |
Sequence modifications
A: 1 - 276 (UniProt: P01892)
B: 1 - 99 (UniProt: P61769)
P: 1 - 10 (UniProt: Q16655)
PDB | External Database | Details |
---|---|---|
Val 245 | Ala 269 | engineered mutation |
Gly 277 | - | expression tag |
Ser 278 | - | expression tag |
Leu 279 | - | expression tag |
His 280 | - | expression tag |
His 281 | - | expression tag |
Ile 282 | - | expression tag |
Leu 283 | - | expression tag |
Asp 284 | - | expression tag |
Ala 285 | - | expression tag |
Gln 286 | - | expression tag |
Lys 287 | - | expression tag |
Met 288 | - | expression tag |
Val 289 | - | expression tag |
Trp 290 | - | expression tag |
Asn 291 | - | expression tag |
His 292 | - | expression tag |
Arg 293 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Met 0 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Leu 2 | Ala 27 | SEE REMARK 999 |
Leu 5 | Ile 30 | engineered mutation |
Asn 8 | Leu 33 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 46874.2 | |
All* | Total formula weight | 46874.2 |