3MOW
Crystal structure of SHP2 in complex with a tautomycetin analog TTN D-1
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Tyrosine-protein phosphatase non-receptor type 11 | polymer | 276 | 32277.7 | 1 | UniProt (Q06124) Pfam (PF00102) In PDB | Homo sapiens (human) | Protein-tyrosine phosphatase 2C, PTP-2C, Protein-tyrosine phosphatase 1D, PTP-1D, SH-PTP3, SH-PTP2, SHP-2, Shp2 |
2 | A | (2Z)-2-[(1R)-3-{[(1R,2S,3R,6S,7S,10S,12S,15E,17E)-18-carboxy-16-ethyl-3,7-dihydroxy-1,2,6,10,12-pentamethyl-5-oxooctade ca-15,17-dien-1-yl]oxy}-1-hydroxy-3-oxopropyl]-3-methylbut-2-enedioic acid | non-polymer | 654.8 | 1 | Chemie (B2B) | |||
3 | water | water | 18.0 | 156 | Chemie (HOH) |
Sequence modifications
A: 262 - 528 (UniProt: Q06124)
PDB | External Database | Details |
---|---|---|
Met 261 | - | initiating methionine |
- | Gln 408 | variant |
- | Ala 409 | variant |
- | Leu 410 | variant |
- | Leu 411 | variant |
Leu 529 | - | expression tag |
Glu 530 | - | expression tag |
His 531 | - | expression tag |
His 532 | - | expression tag |
His 533 | - | expression tag |
His 534 | - | expression tag |
His 535 | - | expression tag |
His 536 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 32277.7 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 654.8 | |
All* | Total formula weight | 32932.5 |