3ML5
Crystal structure of the C183S/C217S mutant of human CA VII in complex with acetazolamide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Carbonic anhydrase 7 | polymer | 269 | 30108.7 | 1 | UniProt (P43166) Pfam (PF00194) | Homo sapiens (human) | Carbonic anhydrase VII, CA-VII, Carbonate dehydratase VII |
| 2 | B (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 3 | C (A) | 5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE | non-polymer | 222.2 | 1 | Chemie (AZM) | |||
| 4 | D (A) | water | water | 18.0 | 261 | Chemie (HOH) |
Sequence modifications
A: -1 - 262 (UniProt: P43166)
| PDB | External Database | Details |
|---|---|---|
| Gly -6 | - | expression tag |
| Ser -5 | - | expression tag |
| Pro -4 | - | expression tag |
| Asn -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Ser 183 | Cys 185 | engineered mutation |
| Ser 217 | Cys 219 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 30108.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 287.7 | |
| All* | Total formula weight | 30396.4 |
