3MI9

Crystal structure of HIV-1 Tat complexed with human P-TEFb

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Cell division protein kinase 9	polymer	351	40692.2	1	UniProt (P50750) Pfam (PF00069)	Homo sapiens (human)	Cyclin-dependent kinase 9, Serine/threonine-protein kinase PITALRE, Cell division cycle 2-like protein kinase 4, C-2K
2	B (B)	Cyclin-T1	polymer	266	30877.3	1	UniProt (O60563) Pfam (PF00134) Pfam (PF21797)	Homo sapiens (human)	Cyclin-T, CycT1
3	C (C)	Protein Tat	polymer	86	9848.3	1	UniProt (P04608) Pfam (PF00539)	Human immunodeficiency virus type 1 (HIV-1)	Transactivating regulatory protein
4	D, E (C)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
5	F, G, H (A, B, C)	water	water		18.0	341	Chemie (HOH)

Sequence modifications

A: 1 - 345 (UniProt: P50750)

PDB	External Database	Details
His 346	-	expression tag
His 347	-	expression tag
His 348	-	expression tag
His 349	-	expression tag
His 350	-	expression tag
His 351	-	expression tag

C: 1 - 86 (UniProt: P04608)

PDB	External Database	Details
Ser 77	Pro 77	variant

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	81417.8
Non-Polymers*	Number of molecules	2
	Total formula weight	130.8
All*	Total formula weight	81548.6

*Water molecules are not included.