3MF5
Hepatitis C virus polymerase NS5B (BK) with amide bioisostere thumb site inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | RNA-directed RNA polymerase | polymer | 570 | 63354.7 | 2 | UniProt (P26663) Pfam (PF00998) | Hepatitis C virus (HCV) | NS5B,p68 |
| 2 | C, E (A, B) | 3-[2-(trans-4-methylcyclohexyl)phenyl]-5-phenylthiophene-2-carboxylic acid | non-polymer | 376.5 | 2 | Chemie (HJZ) | |||
| 3 | D (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 4 | F, G (A, B) | water | water | 18.0 | 631 | Chemie (HOH) |
Sequence modifications
A, B: 2 - 570 (UniProt: P26663)
| PDB | External Database | Details |
|---|---|---|
| His 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 126709.4 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 845.1 | |
| All* | Total formula weight | 127554.6 |
