3MCN

Crystal Structure of the 6-hyroxymethyl-7,8-dihydropterin pyrophosphokinase dihydropteroate synthase bifunctional enzyme from Francisella tularensis

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase/dihydropteroate synthase	polymer	442	50587.3	2	UniProt (Q2A2W3)	Francisella tularensis subsp. holarctica
2	C, F, G (A, B)	MAGNESIUM ION	non-polymer		24.3	3	Chemie (MG)
3	D, E (B)	2,6-diamino-5-nitropyrimidin-4(3H)-one	non-polymer		171.1	2	Chemie (B57)
4	H, I (A, B)	water	water		18.0	165	Chemie (HOH)

Sequence modifications

A, B: 3 - 422 (UniProt: Q2A2W3)

PDB	External Database	Details
Met -19	-	expression tag
Gly -18	-	expression tag
Ser -17	-	expression tag
Ser -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
Ser -9	-	expression tag
Ser -8	-	expression tag
Gly -7	-	expression tag
Leu -6	-	expression tag
Val -5	-	expression tag
Pro -4	-	expression tag
Arg -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
His 0	-	expression tag
Met 1	-	expression tag
Val 2	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	101174.5
Non-Polymers*	Number of molecules	5
	Total formula weight	415.1
All*	Total formula weight	101589.7

*Water molecules are not included.