3MCN
Crystal Structure of the 6-hyroxymethyl-7,8-dihydropterin pyrophosphokinase dihydropteroate synthase bifunctional enzyme from Francisella tularensis
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003848 | molecular_function | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity |
| A | 0004156 | molecular_function | dihydropteroate synthase activity |
| A | 0009396 | biological_process | folic acid-containing compound biosynthetic process |
| A | 0042558 | biological_process | pteridine-containing compound metabolic process |
| B | 0003848 | molecular_function | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity |
| B | 0004156 | molecular_function | dihydropteroate synthase activity |
| B | 0009396 | biological_process | folic acid-containing compound biosynthetic process |
| B | 0042558 | biological_process | pteridine-containing compound metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE MG A 423 |
| Chain | Residue |
| A | ASP101 |
| A | ASP103 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE B57 B 423 |
| Chain | Residue |
| B | ASP255 |
| B | ASN277 |
| B | ILE301 |
| B | ASP346 |
| B | LYS383 |
| B | ARG418 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE B57 B 424 |
| Chain | Residue |
| B | PHE59 |
| B | ASN61 |
| B | ASP101 |
| B | PHE129 |
| B | MG425 |
| B | HOH496 |
| B | GLY9 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG B 425 |
| Chain | Residue |
| B | GLY7 |
| B | ASP101 |
| B | ASP103 |
| B | B57424 |
| B | HOH460 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG B 426 |
| Chain | Residue |
| B | GLU83 |
| B | ASP101 |
| B | LEU102 |
| B | ASP103 |
Functional Information from PROSITE/UniProt
| site_id | PS00793 |
| Number of Residues | 14 |
| Details | DHPS_2 Dihydropteroate synthase signature 2. GAeIIDIGAesTkP |
| Chain | Residue | Details |
| A | GLY205-PRO218 |
