3MBW

Crystal structure of the human ephrin A2 LBD and CRD domains in complex with ephrin A1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Ephrin type-A receptor 2	polymer	330	36587.0	1	UniProt (P29317) Pfam (PF01404)	Homo sapiens (human)	Tyrosine-protein kinase receptor ECK, Epithelial cell kinase
2	B (B)	Ephrin-A1	polymer	181	21398.7	1	UniProt (P20827) Pfam (PF00812)	Homo sapiens (human)	EPH-related receptor tyrosine kinase ligand 1, LERK-1, Immediate early response protein B61, Tumor necrosis factor alpha-induced protein 4, TNF alpha-induced protein 4, Ephrin-A1, secreted form
3	C (C)	alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		748.7	1	In PDB GlyTouCan (G81315DD)
4	D (A)	UNKNOWN ATOM OR ION	non-polymer			1	Chemie (UNX)
5	E, F (A, B)	water	water		18.0	27	Chemie (HOH)

Sequence modifications

A: 23 - 326 (UniProt: P29317)

PDB	External Database	Details
Ala -3	-	expression tag
Pro -2	-	expression tag
Glu -1	-	expression tag
His 0	-	expression tag
His 1	-	expression tag
His 2	-	expression tag
His 3	-	expression tag
His 4	-	expression tag
His 5	-	expression tag
Asp 6	-	expression tag
Tyr 7	-	expression tag
Asp 8	-	expression tag
Ile 9	-	expression tag
Pro 10	-	expression tag
Thr 11	-	expression tag
Thr 12	-	expression tag
Glu 13	-	expression tag
Asn 14	-	expression tag
Leu 15	-	expression tag
Tyr 16	-	expression tag
Phe 17	-	expression tag
Gln 18	-	expression tag
Gly 19	-	expression tag
Ala 20	-	expression tag
Met 21	-	expression tag
Asp 22	-	expression tag

B: 17 - 171 (UniProt: P20827)

PDB	External Database	Details
Ala -9	-	expression tag
Pro -8	-	expression tag
Glu -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
Asp 0	-	expression tag
Tyr 1	-	expression tag
Asp 2	-	expression tag
Ile 3	-	expression tag
Pro 4	-	expression tag
Thr 5	-	expression tag
Thr 6	-	expression tag
Glu 7	-	expression tag
Asn 8	-	expression tag
Leu 9	-	expression tag
Tyr 10	-	expression tag
Phe 11	-	expression tag
Gln 12	-	expression tag
Gly 13	-	expression tag
Ala 14	-	expression tag
Met 15	-	expression tag
Asp 16	-	expression tag
Val 159	Asp 159	SEE REMARK 999

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	57985.7
Branched	Number of molecules	1
	Total formula weight	748.7
Non-Polymers*	Number of molecules	1
	Total formula weight	0.0
All*	Total formula weight	58734.4

*Water molecules are not included.