3M1I
Crystal structure of yeast CRM1 (Xpo1p) in complex with yeast RanBP1 (Yrb1p) and yeast RanGTP (Gsp1pGTP)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | GTP-binding nuclear protein GSP1/CNR1 | polymer | 219 | 24825.4 | 1 | UniProt (P32835) Pfam (PF00071) In PDB | Saccharomyces cerevisiae (yeast) | RanGTP, Gsp1pGTP, GTPase Ran homolog, Genetic suppressor of PRP20-1, Chromosome stability protein 17 |
| 2 | B | Ran-specific GTPase-activating protein 1 | polymer | 191 | 21893.8 | 1 | UniProt (P41920) Pfam (PF00638) In PDB | Saccharomyces cerevisiae (yeast) | Yrb1p, Ran-binding protein 1, RANBP1, Perinuclear array-localized protein, Chromosome stability protein 20 |
| 3 | C | Exportin-1 | polymer | 1049 | 120398.2 | 1 | UniProt (P30822) Pfam (PF03810) Pfam (PF08389) Pfam (PF18777) Pfam (PF18784) Pfam (PF18787) Pfam (PF08767) In PDB | Saccharomyces cerevisiae (yeast) | CRM1, Xpo1p, Chromosome region maintenance protein 1, Karyopherin-124 |
| 4 | A | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 1 | Chemie (GTP) | |||
| 5 | A | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 6 | water | water | 18.0 | 769 | Chemie (HOH) |
Sequence modifications
A: 1 - 219 (UniProt: P32835)
B: 11 - 201 (UniProt: P41920)
C: 1 - 1084 (UniProt: P30822)
| PDB | External Database | Details |
|---|---|---|
| Leu 71 | Gln 71 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| - | Met 1 | deletion |
| - | Ser 2 | deletion |
| - | Ser 3 | deletion |
| - | Glu 4 | deletion |
| - | Asp 5 | deletion |
| - | Lys 6 | deletion |
| - | Lys 7 | deletion |
| - | Pro 8 | deletion |
| - | Val 9 | deletion |
| - | Val 10 | deletion |
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Ala 0 | - | expression tag |
| - | Val 377 | deletion |
| - | Gln 378 | deletion |
| - | Arg 379 | deletion |
| - | Leu 380 | deletion |
| - | Pro 381 | deletion |
| - | Ala 382 | deletion |
| - | Thr 383 | deletion |
| - | Glu 384 | deletion |
| - | Met 385 | deletion |
| - | Ser 386 | deletion |
| - | Pro 387 | deletion |
| - | Leu 388 | deletion |
| - | Ile 389 | deletion |
| - | Gln 390 | deletion |
| - | Leu 391 | deletion |
| - | Ser 392 | deletion |
| - | Val 393 | deletion |
| - | Gly 394 | deletion |
| - | Ser 395 | deletion |
| - | Gln 396 | deletion |
| - | Ala 397 | deletion |
| - | Ile 398 | deletion |
| - | Ser 399 | deletion |
| - | Thr 400 | deletion |
| - | Gly 401 | deletion |
| - | Ser 402 | deletion |
| - | Gly 403 | deletion |
| - | Ala 404 | deletion |
| - | Leu 405 | deletion |
| - | Asn 406 | deletion |
| - | Pro 407 | deletion |
| - | Glu 408 | deletion |
| - | Tyr 409 | deletion |
| - | Met 410 | deletion |
| - | Lys 411 | deletion |
| - | Arg 412 | deletion |
| - | Phe 413 | deletion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 167117.3 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 547.5 | |
| All* | Total formula weight | 167664.8 |
