3M09
F98Y TMP-resistant Dihydrofolate Reductase from Staphylococcus aureus with inhibitor RAB1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Dihydrofolate reductase | polymer | 161 | 18456.1 | 1 | UniProt (P0A017) | Staphylococcus aureus | DHFR |
| 2 | B (A) | 5-(3,4-dimethoxy-5-{(1E)-3-oxo-3-[(1S)-1-propylphthalazin-2(1H)-yl]prop-1-en-1-yl}benzyl)pyrimidine-2,4-diamine | non-polymer | 486.6 | 1 | Chemie (RAR) PubChem (42627761) PubChem (49821325) PubChem (74829628) | |||
| 3 | C (A) | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 1 | Chemie (NAP) PubChem (5885) PubChem (46936685) PubChem (71717786) PubChem (4412) PubChem (90473931) PubChem (91972139) PubChem (145946263) PubChem (153311489) PubChem (174001641) PubChem (165382010) | |||
| 4 | D (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) PubChem (753) | |||
| 5 | E (A) | water | water | 18.0 | 166 | Chemie (HOH) |
Sequence modifications
A: 1 - 157 (UniProt: P0A017)
| PDB | External Database | Details |
|---|---|---|
| Tyr 98 | Phe 99 | engineered mutation |
| Ala 158 | - | expression tag |
| Val 159 | - | expression tag |
| Pro 160 | - | expression tag |
| Arg 161 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 18456.1 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1322.1 | |
| All* | Total formula weight | 19778.1 |
