Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004146 | molecular_function | dihydrofolate reductase activity |
A | 0005829 | cellular_component | cytosol |
A | 0006730 | biological_process | one-carbon metabolic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0046452 | biological_process | dihydrofolate metabolic process |
A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
A | 0046655 | biological_process | folic acid metabolic process |
A | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 19 |
Details | BINDING SITE FOR RESIDUE RAR A 200 |
Chain | Residue |
A | LEU5 |
A | ILE50 |
A | LYS52 |
A | LEU54 |
A | PRO55 |
A | ARG57 |
A | PHE92 |
A | TYR98 |
A | NAP201 |
A | HOH230 |
A | HOH261 |
A | VAL6 |
A | ALA7 |
A | ASP27 |
A | LEU28 |
A | LYS29 |
A | VAL31 |
A | LYS32 |
A | SER49 |
site_id | AC2 |
Number of Residues | 33 |
Details | BINDING SITE FOR RESIDUE NAP A 201 |
Chain | Residue |
A | VAL6 |
A | ALA7 |
A | ILE14 |
A | GLY15 |
A | PHE16 |
A | ASN18 |
A | GLN19 |
A | LEU20 |
A | TRP22 |
A | GLY43 |
A | ARG44 |
A | LYS45 |
A | THR46 |
A | LEU62 |
A | THR63 |
A | SER64 |
A | HIS77 |
A | ILE79 |
A | PHE92 |
A | GLY93 |
A | GLY94 |
A | GLN95 |
A | THR96 |
A | TYR98 |
A | GLU100 |
A | THR121 |
A | HOH166 |
A | HOH176 |
A | HOH188 |
A | HOH193 |
A | HOH198 |
A | RAR200 |
A | HOH245 |
site_id | AC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE GOL A 202 |
Chain | Residue |
A | ARG12 |
A | PRO125 |
A | TYR126 |
A | PHE128 |
A | GLU132 |
A | HOH195 |
Functional Information from PROSITE/UniProt
site_id | PS00075 |
Number of Residues | 23 |
Details | DHFR_1 Dihydrofolate reductase (DHFR) domain signature. VIGfenqLPWhlpn.DlkhVkklS |
Chain | Residue | Details |
A | VAL13-SER35 | |
Functional Information from SwissProt/UniProt
Chain | Residue | Details |
A | LEU5 | |
A | ASP27 | |
A | SER49 | |
A | ARG57 | |
A | PHE92 | |
Chain | Residue | Details |
A | VAL6 | |
A | ILE14 | |
A | GLY43 | |
A | LEU62 | |
A | GLU100 | |
A | THR121 | |