3LW0
IGF-1RK in complex with ligand MSC1609119A-1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Insulin-like growth factor 1 receptor | polymer | 304 | 34607.8 | 4 | UniProt (P08069) Pfam (PF07714) | Homo sapiens (human) | IGF-1 RECEPTOR KINASE, Insulin-like growth factor I receptor, IGF-I receptor, Insulin-like growth factor 1 receptor alpha chain, Insulin-like growth factor 1 receptor beta chain |
| 2 | E, F, G, H, J... (A, B, C, D) | 3-cyano-N-{1-[4-(5-cyano-1H-indol-3-yl)butyl]piperidin-4-yl}-1H-indole-7-carboxamide | non-polymer | 464.6 | 8 | Chemie (CCX) | |||
| 3 | I, L (B, C) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 4 | O, P, Q, R (A, B, C, D) | water | water | 18.0 | 1049 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 983 - 1286 (UniProt: P08069)
| PDB | External Database | Details |
|---|---|---|
| Ala 1097 | Glu 1097 | engineered mutation |
| Ala 1099 | Glu 1099 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 138431.0 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 3900.7 | |
| All* | Total formula weight | 142331.7 |
