3LW0
IGF-1RK in complex with ligand MSC1609119A-1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004713 | molecular_function | protein tyrosine kinase activity |
| A | 0004714 | molecular_function | transmembrane receptor protein tyrosine kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006468 | biological_process | protein phosphorylation |
| A | 0007169 | biological_process | cell surface receptor protein tyrosine kinase signaling pathway |
| A | 0016020 | cellular_component | membrane |
| B | 0004672 | molecular_function | protein kinase activity |
| B | 0004713 | molecular_function | protein tyrosine kinase activity |
| B | 0004714 | molecular_function | transmembrane receptor protein tyrosine kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006468 | biological_process | protein phosphorylation |
| B | 0007169 | biological_process | cell surface receptor protein tyrosine kinase signaling pathway |
| B | 0016020 | cellular_component | membrane |
| C | 0004672 | molecular_function | protein kinase activity |
| C | 0004713 | molecular_function | protein tyrosine kinase activity |
| C | 0004714 | molecular_function | transmembrane receptor protein tyrosine kinase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0006468 | biological_process | protein phosphorylation |
| C | 0007169 | biological_process | cell surface receptor protein tyrosine kinase signaling pathway |
| C | 0016020 | cellular_component | membrane |
| D | 0004672 | molecular_function | protein kinase activity |
| D | 0004713 | molecular_function | protein tyrosine kinase activity |
| D | 0004714 | molecular_function | transmembrane receptor protein tyrosine kinase activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0006468 | biological_process | protein phosphorylation |
| D | 0007169 | biological_process | cell surface receptor protein tyrosine kinase signaling pathway |
| D | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE CCX A 1 |
| Chain | Residue |
| A | HOH355 |
| A | HOH450 |
| A | ALA1051 |
| A | MET1054 |
| A | VAL1063 |
| A | HIS1133 |
| A | ILE1151 |
| A | GLY1152 |
| site_id | AC2 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE CCX A 1287 |
| Chain | Residue |
| A | HOH352 |
| A | HOH361 |
| A | HOH787 |
| A | TYR1090 |
| A | GLN1114 |
| A | MET1115 |
| A | GLU1118 |
| A | ASP1146 |
| A | PHE1147 |
| A | THR1148 |
| A | GLU1271 |
| A | PRO1272 |
| A | GLY1273 |
| D | HOH471 |
| D | GLY1273 |
| D | PHE1274 |
| D | VAL1277 |
| D | CCX1287 |
| A | HOH289 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE CCX B 2 |
| Chain | Residue |
| B | HOH267 |
| B | HOH446 |
| B | ALA1051 |
| B | MET1054 |
| B | VAL1063 |
| B | HIS1133 |
| B | ILE1151 |
| B | GLY1152 |
| site_id | AC4 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE CCX B 1287 |
| Chain | Residue |
| B | HOH292 |
| B | HOH635 |
| B | HOH772 |
| B | TYR1090 |
| B | MET1115 |
| B | GLU1118 |
| B | ASP1146 |
| B | PHE1147 |
| B | THR1148 |
| B | GLU1271 |
| B | PRO1272 |
| B | GLY1273 |
| C | HOH444 |
| C | GLY1273 |
| C | PHE1274 |
| C | VAL1277 |
| C | CCX1287 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL B 1 |
| Chain | Residue |
| B | HOH441 |
| B | SER1110 |
| B | GLN1114 |
| B | GLU1271 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE CCX C 3 |
| Chain | Residue |
| C | HOH219 |
| C | HOH403 |
| C | ALA1051 |
| C | MET1054 |
| C | VAL1063 |
| C | VAL1077 |
| C | HIS1133 |
| C | ILE1151 |
| C | GLY1152 |
| site_id | AC7 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE CCX C 1287 |
| Chain | Residue |
| B | HOH510 |
| B | GLY1273 |
| B | PHE1274 |
| B | VAL1277 |
| B | CCX1287 |
| C | HOH290 |
| C | HOH611 |
| C | HOH800 |
| C | TYR1090 |
| C | MET1115 |
| C | GLU1118 |
| C | ASP1146 |
| C | PHE1147 |
| C | THR1148 |
| C | GLU1271 |
| C | PRO1272 |
| C | GLY1273 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL C 2 |
| Chain | Residue |
| C | PHE1224 |
| C | GLU1227 |
| C | GLY1229 |
| C | ASN1236 |
| site_id | AC9 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE CCX D 4 |
| Chain | Residue |
| D | HOH253 |
| D | HOH485 |
| D | ALA1051 |
| D | MET1054 |
| D | VAL1063 |
| D | HIS1133 |
| D | ILE1151 |
| D | GLY1152 |
| site_id | BC1 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE CCX D 1287 |
| Chain | Residue |
| D | HOH304 |
| D | HOH939 |
| D | TYR1090 |
| D | GLN1114 |
| D | MET1115 |
| D | GLU1118 |
| D | ASP1146 |
| D | PHE1147 |
| D | THR1148 |
| D | GLU1271 |
| D | PRO1272 |
| D | GLY1273 |
| A | HOH492 |
| A | GLY1273 |
| A | PHE1274 |
| A | VAL1277 |
| A | CCX1287 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 29 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGQGSFGMVYeGvakgvvkdepetr.....VAIK |
| Chain | Residue | Details |
| A | LEU1005-LYS1033 |
| site_id | PS00109 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. FVHrDLAARNCMV |
| Chain | Residue | Details |
| A | PHE1131-VAL1143 |
| site_id | PS00239 |
| Number of Residues | 9 |
| Details | RECEPTOR_TYR_KIN_II Receptor tyrosine kinase class II signature. DIYetdYYR |
| Chain | Residue | Details |
| A | ASP1159-ARG1167 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10028","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 32 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | Modified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"PubMed","id":"11694888","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18501599","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19041240","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26584640","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"PubMed","id":"11694888","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18501599","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19041240","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine; by GSK3-beta","evidences":[{"source":"UniProtKB","id":"Q60751","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q60751","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 8 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"21994939","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
