3LW0
IGF-1RK in complex with ligand MSC1609119A-1
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004672 | molecular_function | protein kinase activity |
A | 0004713 | molecular_function | protein tyrosine kinase activity |
A | 0004714 | molecular_function | transmembrane receptor protein tyrosine kinase activity |
A | 0005524 | molecular_function | ATP binding |
A | 0006468 | biological_process | protein phosphorylation |
A | 0007169 | biological_process | cell surface receptor protein tyrosine kinase signaling pathway |
A | 0016020 | cellular_component | membrane |
B | 0004672 | molecular_function | protein kinase activity |
B | 0004713 | molecular_function | protein tyrosine kinase activity |
B | 0004714 | molecular_function | transmembrane receptor protein tyrosine kinase activity |
B | 0005524 | molecular_function | ATP binding |
B | 0006468 | biological_process | protein phosphorylation |
B | 0007169 | biological_process | cell surface receptor protein tyrosine kinase signaling pathway |
B | 0016020 | cellular_component | membrane |
C | 0004672 | molecular_function | protein kinase activity |
C | 0004713 | molecular_function | protein tyrosine kinase activity |
C | 0004714 | molecular_function | transmembrane receptor protein tyrosine kinase activity |
C | 0005524 | molecular_function | ATP binding |
C | 0006468 | biological_process | protein phosphorylation |
C | 0007169 | biological_process | cell surface receptor protein tyrosine kinase signaling pathway |
C | 0016020 | cellular_component | membrane |
D | 0004672 | molecular_function | protein kinase activity |
D | 0004713 | molecular_function | protein tyrosine kinase activity |
D | 0004714 | molecular_function | transmembrane receptor protein tyrosine kinase activity |
D | 0005524 | molecular_function | ATP binding |
D | 0006468 | biological_process | protein phosphorylation |
D | 0007169 | biological_process | cell surface receptor protein tyrosine kinase signaling pathway |
D | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE CCX A 1 |
Chain | Residue |
A | HOH355 |
A | HOH450 |
A | ALA1051 |
A | MET1054 |
A | VAL1063 |
A | HIS1133 |
A | ILE1151 |
A | GLY1152 |
site_id | AC2 |
Number of Residues | 19 |
Details | BINDING SITE FOR RESIDUE CCX A 1287 |
Chain | Residue |
A | HOH352 |
A | HOH361 |
A | HOH787 |
A | TYR1090 |
A | GLN1114 |
A | MET1115 |
A | GLU1118 |
A | ASP1146 |
A | PHE1147 |
A | THR1148 |
A | GLU1271 |
A | PRO1272 |
A | GLY1273 |
D | HOH471 |
D | GLY1273 |
D | PHE1274 |
D | VAL1277 |
D | CCX1287 |
A | HOH289 |
site_id | AC3 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE CCX B 2 |
Chain | Residue |
B | HOH267 |
B | HOH446 |
B | ALA1051 |
B | MET1054 |
B | VAL1063 |
B | HIS1133 |
B | ILE1151 |
B | GLY1152 |
site_id | AC4 |
Number of Residues | 17 |
Details | BINDING SITE FOR RESIDUE CCX B 1287 |
Chain | Residue |
B | HOH292 |
B | HOH635 |
B | HOH772 |
B | TYR1090 |
B | MET1115 |
B | GLU1118 |
B | ASP1146 |
B | PHE1147 |
B | THR1148 |
B | GLU1271 |
B | PRO1272 |
B | GLY1273 |
C | HOH444 |
C | GLY1273 |
C | PHE1274 |
C | VAL1277 |
C | CCX1287 |
site_id | AC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE GOL B 1 |
Chain | Residue |
B | HOH441 |
B | SER1110 |
B | GLN1114 |
B | GLU1271 |
site_id | AC6 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE CCX C 3 |
Chain | Residue |
C | HOH219 |
C | HOH403 |
C | ALA1051 |
C | MET1054 |
C | VAL1063 |
C | VAL1077 |
C | HIS1133 |
C | ILE1151 |
C | GLY1152 |
site_id | AC7 |
Number of Residues | 17 |
Details | BINDING SITE FOR RESIDUE CCX C 1287 |
Chain | Residue |
B | HOH510 |
B | GLY1273 |
B | PHE1274 |
B | VAL1277 |
B | CCX1287 |
C | HOH290 |
C | HOH611 |
C | HOH800 |
C | TYR1090 |
C | MET1115 |
C | GLU1118 |
C | ASP1146 |
C | PHE1147 |
C | THR1148 |
C | GLU1271 |
C | PRO1272 |
C | GLY1273 |
site_id | AC8 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE GOL C 2 |
Chain | Residue |
C | PHE1224 |
C | GLU1227 |
C | GLY1229 |
C | ASN1236 |
site_id | AC9 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE CCX D 4 |
Chain | Residue |
D | HOH253 |
D | HOH485 |
D | ALA1051 |
D | MET1054 |
D | VAL1063 |
D | HIS1133 |
D | ILE1151 |
D | GLY1152 |
site_id | BC1 |
Number of Residues | 17 |
Details | BINDING SITE FOR RESIDUE CCX D 1287 |
Chain | Residue |
D | HOH304 |
D | HOH939 |
D | TYR1090 |
D | GLN1114 |
D | MET1115 |
D | GLU1118 |
D | ASP1146 |
D | PHE1147 |
D | THR1148 |
D | GLU1271 |
D | PRO1272 |
D | GLY1273 |
A | HOH492 |
A | GLY1273 |
A | PHE1274 |
A | VAL1277 |
A | CCX1287 |
Functional Information from PROSITE/UniProt
site_id | PS00107 |
Number of Residues | 29 |
Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGQGSFGMVYeGvakgvvkdepetr.....VAIK |
Chain | Residue | Details |
A | LEU1005-LYS1033 |
site_id | PS00109 |
Number of Residues | 13 |
Details | PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. FVHrDLAARNCMV |
Chain | Residue | Details |
A | PHE1131-VAL1143 |
site_id | PS00239 |
Number of Residues | 9 |
Details | RECEPTOR_TYR_KIN_II Receptor tyrosine kinase class II signature. DIYetdYYR |
Chain | Residue | Details |
A | ASP1159-ARG1167 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028 |
Chain | Residue | Details |
A | ASP1135 | |
B | ASP1135 | |
C | ASP1135 | |
D | ASP1135 |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 |
Chain | Residue | Details |
A | LEU1005 | |
B | LEU1005 | |
C | LEU1005 | |
D | LEU1005 |
site_id | SWS_FT_FI3 |
Number of Residues | 4 |
Details | BINDING: |
Chain | Residue | Details |
A | LYS1033 | |
B | LYS1033 | |
C | LYS1033 | |
D | LYS1033 |
site_id | SWS_FT_FI4 |
Number of Residues | 12 |
Details | MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:11694888, ECO:0000269|PubMed:18501599, ECO:0000269|PubMed:19041240 |
Chain | Residue | Details |
A | TYR1161 | |
D | TYR1161 | |
D | TYR1165 | |
D | TYR1166 | |
A | TYR1165 | |
A | TYR1166 | |
B | TYR1161 | |
B | TYR1165 | |
B | TYR1166 | |
C | TYR1161 | |
C | TYR1165 | |
C | TYR1166 |
site_id | SWS_FT_FI5 |
Number of Residues | 4 |
Details | MOD_RES: Phosphoserine; by GSK3-beta => ECO:0000250|UniProtKB:Q60751 |
Chain | Residue | Details |
A | SER1278 | |
B | SER1278 | |
C | SER1278 | |
D | SER1278 |
site_id | SWS_FT_FI6 |
Number of Residues | 4 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q60751 |
Chain | Residue | Details |
A | SER1282 | |
B | SER1282 | |
C | SER1282 | |
D | SER1282 |
site_id | SWS_FT_FI7 |
Number of Residues | 12 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:21994939 |
Chain | Residue | Details |
A | LYS1168 | |
D | LYS1168 | |
D | LYS1171 | |
A | LYS1171 | |
B | LYS1168 | |
B | LYS1171 | |
C | LYS1168 | |
C | LYS1171 |