3LV2

Crystal structure of Mycobacterium tuberculosis 7,8-diaminopelargonic acid synthase in complex with substrate analog sinefungin

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase	polymer	462	49226.2	2	UniProt (P0A4X6) Pfam (PF00202) UniProt (by SIFTS) (P9WQ81)	Mycobacterium tuberculosis	7,8-diamino-pelargonic acid aminotransferase, DAPA aminotransferase, DAPA AT, Diaminopelargonic acid synthase
2	C, E (A, B)	PYRIDOXAL-5'-PHOSPHATE	non-polymer		247.1	2	Chemie (PLP)
3	D (A)	SINEFUNGIN	non-polymer		381.4	1	Chemie (SFG)
4	F, G (A, B)	water	water		18.0	305	Chemie (HOH)

Sequence modifications

A, B: 1 - 437 (UniProt: P0A4X6)

PDB	External Database	Details
Met -24	-	expression tag
Gly -23	-	expression tag
Ser -22	-	expression tag
Ser -21	-	expression tag
His -20	-	expression tag
His -19	-	expression tag
His -18	-	expression tag
His -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
Ser -14	-	expression tag
Ser -13	-	expression tag
Gly -12	-	expression tag
Leu -11	-	expression tag
Gln -10	-	expression tag
Gly -9	-	expression tag
Thr -8	-	expression tag
Glu -7	-	expression tag
Asn -6	-	expression tag
Leu -5	-	expression tag
Tyr -4	-	expression tag
Phe -3	-	expression tag
Gln -2	-	expression tag
Ser -1	-	expression tag
His 0	-	expression tag
Arg 315	His 315	SEE REMARK 999

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	98452.4
Non-Polymers*	Number of molecules	3
	Total formula weight	875.7
All*	Total formula weight	99328.1

*Water molecules are not included.