3LTL

Crystal structure of human BIG1 Sec7 domain

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Brefeldin A-inhibited guanine nucleotide-exchange protein 1	polymer	211	24391.6	2	UniProt (Q9Y6D6) Pfam (PF01369)	Homo sapiens (human)	Brefeldin A-inhibited GEP 1, p200 ARF-GEP1, p200 ARF guanine nucleotide exchange factor
2	C, D (A)	CALCIUM ION	non-polymer		40.1	2	Chemie (CA)
3	E (A)	ACETIC ACID	non-polymer		60.1	1	Chemie (ACY)
4	F, G (A, B)	water	water		18.0	73	Chemie (HOH)

Sequence modifications

A, B: 691 - 889 (UniProt: Q9Y6D6)

PDB	External Database	Details
Met 681	-	expression tag
Gly 682	-	expression tag
His 683	-	expression tag
His 684	-	expression tag
His 685	-	expression tag
His 686	-	expression tag
His 687	-	expression tag
His 688	-	expression tag
Gly 689	-	expression tag
Thr 690	-	expression tag
Thr 890	-	expression tag
Gly 891	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	48783.3
Non-Polymers*	Number of molecules	3
	Total formula weight	140.2
All*	Total formula weight	48923.5

*Water molecules are not included.