3LKJ
Small Molecule Inhibition of the TNF Family Cyokine CD40 Ligand Through a Subunit Fracture Mechanism
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C | CD40 ligand | polymer | 141 | 15301.3 | 3 | UniProt (P29965) Pfam (PF00229) In PDB | Homo sapiens (human) | CD40-L, Tumor necrosis factor ligand superfamily member 5, TNF-related activation protein, TRAP, T-cell antigen Gp39, CD40 ligand, membrane form, CD40 ligand, soluble form |
| 2 | A, B, C | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 6 | Chemie (NAG) | |||
| 3 | C | (2R)-{[(2'-[(biphenyl-3-ylmethyl)carbamoyl]-6'-{[(2R)-2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl]carbonyl}-6-{[(2R)-2-(1H-pyrrol-1-ylmethyl)pyrrolidin-1-yl]carbonyl}-4,4'-bipyridin-2-yl)carbonyl]amino}(cyclohexyl)ethanoic acid | non-polymer | 905.1 | 1 | Chemie (LKJ) | |||
| 4 | water | water | 18.0 | 72 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 45904.0 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 2232.3 | |
| All* | Total formula weight | 48136.3 |
