3LHV
Crystal structure of the mutant V182A.I199A.V201A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Orotidine 5'-phosphate decarboxylase | polymer | 228 | 24786.5 | 4 | UniProt (O26232) Pfam (PF00215) | Methanothermobacter thermautotrophicus | OMP decarboxylase, OMPDCase, OMPdecase |
| 2 | E, F, G, H (A, B, C, D) | 1-(5'-PHOSPHO-BETA-D-RIBOFURANOSYL)BARBITURIC ACID | non-polymer | 340.2 | 4 | Chemie (BMQ) | |||
| 3 | I, J, K, L (A, B, C, D) | water | water | 18.0 | 580 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 228 (UniProt: O26232)
| PDB | External Database | Details |
|---|---|---|
| Pro 101 | Arg 101 | engineered mutation |
| Ala 182 | Val 182 | engineered mutation |
| Ala 199 | Ile 199 | engineered mutation |
| Ala 201 | Val 201 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 99146.0 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1360.7 | |
| All* | Total formula weight | 100506.8 |
