3LHV
Crystal structure of the mutant V182A.I199A.V201A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004590 | molecular_function | orotidine-5'-phosphate decarboxylase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| A | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| A | 0016829 | molecular_function | lyase activity |
| A | 0016831 | molecular_function | carboxy-lyase activity |
| A | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| B | 0004590 | molecular_function | orotidine-5'-phosphate decarboxylase activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| B | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| B | 0016829 | molecular_function | lyase activity |
| B | 0016831 | molecular_function | carboxy-lyase activity |
| B | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| C | 0004590 | molecular_function | orotidine-5'-phosphate decarboxylase activity |
| C | 0005829 | cellular_component | cytosol |
| C | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| C | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| C | 0016829 | molecular_function | lyase activity |
| C | 0016831 | molecular_function | carboxy-lyase activity |
| C | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| D | 0004590 | molecular_function | orotidine-5'-phosphate decarboxylase activity |
| D | 0005829 | cellular_component | cytosol |
| D | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| D | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| D | 0016829 | molecular_function | lyase activity |
| D | 0016831 | molecular_function | carboxy-lyase activity |
| D | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE BMQ A 229 |
| Chain | Residue |
| A | ASP20 |
| A | ARG203 |
| A | HOH238 |
| A | HOH240 |
| A | HOH241 |
| A | HOH244 |
| A | HOH245 |
| A | HOH247 |
| A | HOH248 |
| B | ASP75 |
| B | ILE76 |
| A | LYS42 |
| B | THR79 |
| A | ASP70 |
| A | LYS72 |
| A | MET126 |
| A | SER127 |
| A | PRO180 |
| A | GLN185 |
| A | GLY202 |
| site_id | AC2 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE BMQ B 229 |
| Chain | Residue |
| A | ASP75 |
| A | ILE76 |
| A | THR79 |
| B | ASP20 |
| B | LYS42 |
| B | ASP70 |
| B | LYS72 |
| B | MET126 |
| B | SER127 |
| B | PRO180 |
| B | GLN185 |
| B | GLY202 |
| B | ARG203 |
| B | HOH239 |
| B | HOH244 |
| B | HOH246 |
| B | HOH247 |
| B | HOH249 |
| B | HOH251 |
| B | HOH271 |
| site_id | AC3 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE BMQ C 229 |
| Chain | Residue |
| C | ASP20 |
| C | LYS42 |
| C | ASP70 |
| C | LYS72 |
| C | MET126 |
| C | SER127 |
| C | PRO180 |
| C | GLN185 |
| C | GLY202 |
| C | ARG203 |
| C | HOH238 |
| C | HOH241 |
| C | HOH242 |
| C | HOH244 |
| C | HOH246 |
| C | HOH248 |
| C | HOH250 |
| D | ASP75 |
| D | ILE76 |
| D | THR79 |
| site_id | AC4 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE BMQ D 229 |
| Chain | Residue |
| C | ASP75 |
| C | ILE76 |
| C | THR79 |
| D | ASP20 |
| D | LYS42 |
| D | ASP70 |
| D | LYS72 |
| D | MET126 |
| D | SER127 |
| D | PRO180 |
| D | GLN185 |
| D | GLY202 |
| D | ARG203 |
| D | HOH236 |
| D | HOH241 |
| D | HOH244 |
| D | HOH248 |
| D | HOH249 |
| D | HOH251 |
| D | HOH285 |
Functional Information from PROSITE/UniProt
| site_id | PS00156 |
| Number of Residues | 14 |
| Details | OMPDECASE Orotidine 5'-phosphate decarboxylase active site. IIaDfKvaDIPeTN |
| Chain | Residue | Details |
| A | ILE67-ASN80 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton donor"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 96 |
| Details | Binding site: {} |
| Chain | Residue | Details |
