3LBK
Structure of human MDM2 protein in complex with a small molecule inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | E3 ubiquitin-protein ligase Mdm2 | polymer | 95 | 11159.1 | 1 | UniProt (Q00987) Pfam (PF02201) | Homo sapiens (human) | p53-binding protein Mdm2, Oncoprotein Mdm2, Double minute 2 protein, Hdm2 |
| 2 | B (A) | 6-chloro-3-[1-(4-chlorobenzyl)-4-phenyl-1H-imidazol-5-yl]-1H-indole-2-carboxylic acid | non-polymer | 462.3 | 1 | Chemie (K23) | |||
| 3 | C (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 4 | D (A) | water | water | 18.0 | 20 | Chemie (HOH) |
Sequence modifications
A: 18 - 111 (UniProt: Q00987)
| PDB | External Database | Details |
|---|---|---|
| Met 17 | - | expression tag |
| Glu 33 | Leu 33 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 11159.1 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 558.4 | |
| All* | Total formula weight | 11717.5 |
