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3LBK

Structure of human MDM2 protein in complex with a small molecule inhibitor

Functional Information from GO Data
ChainGOidnamespacecontents
A0005634cellular_componentnucleus
A0043066biological_processnegative regulation of apoptotic process
A0051726biological_processregulation of cell cycle
Functional Information from PDB Data
site_idAC1
Number of Residues11
DetailsBINDING SITE FOR RESIDUE K23 A 1
ChainResidue
AHOH4
AILE99
ATYR100
AHOH13
ALEU54
APHE55
AGLY58
AILE61
AMET62
AVAL93
AHIS96

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 A 112
ChainResidue
ALYS94
AGLU95
AHIS96
AARG97

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues83
DetailsDomain: {"description":"SWIB/MDM2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01273","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

247536

PDB entries from 2026-01-14

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