3L0E
X-ray crystal structure of a Potent Liver X Receptor Modulator
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Oxysterols receptor LXR-beta | polymer | 253 | 28711.7 | 1 | UniProt (P55055) Pfam (PF00104) In PDB | Homo sapiens (human) | Liver X receptor beta, Nuclear orphan receptor LXR-beta, Nuclear receptor subfamily 1 group H member 2, Ubiquitously-expressed nuclear receptor, Nuclear receptor NER |
2 | B | Nuclear receptor coactivator 2 | polymer | 12 | 1478.8 | 1 | UniProt (Q15596) In PDB | NCoA-2, Transcriptional intermediary factor 2, hTIF2 | |
3 | A | N-(2-chloro-6-fluorobenzyl)-1-methyl-N-{[3'-(methylsulfonyl)biphenyl-4-yl]methyl}-1H-imidazole-4-sulfonamide | non-polymer | 548.0 | 1 | Chemie (G58) | |||
4 | water | water | 18.0 | 76 | Chemie (HOH) |
Sequence modifications
A: 213 - 461 (UniProt: P55055)
PDB | External Database | Details |
---|---|---|
Gly 209 | - | expression tag |
Ser 210 | - | expression tag |
His 211 | - | expression tag |
Met 212 | - | expression tag |
Ser 238 | Cys 238 | engineered mutation |
Ser 326 | Cys 326 | engineered mutation |
Ser 361 | Arg 361 | engineered mutation |
Ser 362 | Arg 362 | engineered mutation |
Ala 445 | Gln 445 | engineered mutation |
Ala 447 | Lys 447 | engineered mutation |
Ala 448 | Lys 448 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 30190.4 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 548.0 | |
All* | Total formula weight | 30738.5 |