3L0E
X-ray crystal structure of a Potent Liver X Receptor Modulator
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Oxysterols receptor LXR-beta | polymer | 253 | 28711.7 | 1 | UniProt (P55055) Pfam (PF00104) | Homo sapiens (human) | Liver X receptor beta, Nuclear orphan receptor LXR-beta, Nuclear receptor subfamily 1 group H member 2, Ubiquitously-expressed nuclear receptor, Nuclear receptor NER |
| 2 | B (B) | Nuclear receptor coactivator 2 | polymer | 12 | 1478.8 | 1 | UniProt (Q15596) | NCoA-2, Transcriptional intermediary factor 2, hTIF2 | |
| 3 | C (A) | N-(2-chloro-6-fluorobenzyl)-1-methyl-N-{[3'-(methylsulfonyl)biphenyl-4-yl]methyl}-1H-imidazole-4-sulfonamide | non-polymer | 548.0 | 1 | Chemie (G58) | |||
| 4 | D, E (A, B) | water | water | 18.0 | 76 | Chemie (HOH) |
Sequence modifications
A: 213 - 461 (UniProt: P55055)
| PDB | External Database | Details |
|---|---|---|
| Gly 209 | - | expression tag |
| Ser 210 | - | expression tag |
| His 211 | - | expression tag |
| Met 212 | - | expression tag |
| Ser 238 | Cys 238 | engineered mutation |
| Ser 326 | Cys 326 | engineered mutation |
| Ser 361 | Arg 361 | engineered mutation |
| Ser 362 | Arg 362 | engineered mutation |
| Ala 445 | Gln 445 | engineered mutation |
| Ala 447 | Lys 447 | engineered mutation |
| Ala 448 | Lys 448 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 30190.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 548.0 | |
| All* | Total formula weight | 30738.5 |
