3KYD
Human SUMO E1~SUMO1-AMP tetrahedral intermediate mimic
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | SUMO-activating enzyme subunit 1 | polymer | 346 | 38499.8 | 1 | UniProt (Q9UBE0) Pfam (PF00899) | Homo sapiens (human) | Ubiquitin-like 1-activating enzyme E1A |
| 2 | B (B) | SUMO-activating enzyme subunit 2 | polymer | 551 | 61562.2 | 1 | UniProt (Q9UBT2) Pfam (PF00899) Pfam (PF14732) | Homo sapiens (human) | Ubiquitin-like 1-activating enzyme E1B, Anthracycline-associated resistance ARX |
| 3 | C (D) | Small ubiquitin-related modifier 1 | polymer | 115 | 13208.8 | 1 | UniProt (P63165) Pfam (PF11976) | Homo sapiens (human) | SUMO-1, Sentrin, Ubiquitin-like protein SMT3C, SMT3 homolog 3, Ubiquitin-homology domain protein PIC1, Ubiquitin-like protein UBL1, GAP-modifying protein 1, GMP1 |
| 4 | D, E, H (A, D) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
| 5 | F (B) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 6 | G (D) | 5'-{[(3-aminopropyl)sulfonyl]amino}-5'-deoxyadenosine | non-polymer | 387.4 | 1 | Chemie (VMX) | |||
| 7 | I, J, K (A, B, D) | water | water | 18.0 | 215 | Chemie (HOH) |
Sequence modifications
B: 1 - 549 (UniProt: Q9UBT2)
D: 1 - 96 (UniProt: P63165)
| PDB | External Database | Details |
|---|---|---|
| Ser -1 | - | expression tag |
| Leu 0 | - | expression tag |
| Cys 229 | Ser 229 | variant |
| PDB | External Database | Details |
|---|---|---|
| Met -18 | - | expression tag |
| Gly -17 | - | expression tag |
| Ser -16 | - | expression tag |
| Ser -15 | - | expression tag |
| His -14 | - | expression tag |
| His -13 | - | expression tag |
| His -12 | - | expression tag |
| His -11 | - | expression tag |
| His -10 | - | expression tag |
| His -9 | - | expression tag |
| Ser -8 | - | expression tag |
| Ser -7 | - | expression tag |
| Gly -6 | - | expression tag |
| Leu -5 | - | expression tag |
| Val -4 | - | expression tag |
| Pro -3 | - | expression tag |
| Arg -2 | - | expression tag |
| Ser -1 | - | expression tag |
| His 0 | - | expression tag |
| Cys 95 | Thr 95 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 113270.9 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 639.0 | |
| All* | Total formula weight | 113909.9 |
