3KTU
Structure of human 8-oxoGuanine Glycosylase 1 bound to fluorninated oxoG-containing DNA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | N-glycosylase/DNA lyase | polymer | 317 | 35727.5 | 1 | UniProt (O15527) Pfam (PF07934) Pfam (PF00730) | Homo sapiens (human) | 8-oxoguanine DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase |
| 2 | B (B) | DNA (5'-D(*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*C)-3') | polymer | 13 | 4016.6 | 1 | synthetic construct | ||
| 3 | C (C) | DNA (5'-D(*GP*TP*CP*CP*AP*(FDG)P*GP*TP*CP*TP*AP*C)-3') | polymer | 12 | 3672.4 | 1 | synthetic construct | ||
| 4 | D, E (A, C) | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) | |||
| 5 | F, G (A, C) | water | water | 18.0 | 72 | Chemie (HOH) |
Sequence modifications
A: 12 - 325 (UniProt: O15527)
| PDB | External Database | Details |
|---|---|---|
| Ser 9 | - | expression tag |
| Glu 10 | - | expression tag |
| Phe 11 | - | expression tag |
| Cys 149 | Asn 149 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 43416.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 80.2 | |
| All* | Total formula weight | 43496.6 |
