3KRB

Structure of Aldose Reductase from Giardia Lamblia at 1.75A Resolution

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Aldose reductase	polymer	334	37799.2	2	UniProt (A8BGX6) Pfam (PF00248)	Giardia lamblia
2	C, G (A, B)	NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	non-polymer		743.4	2	Chemie (NAP)
3	D, H (A, B)	UNKNOWN ATOM OR ION	non-polymer			2	Chemie (UNX)
4	E, F (A, B)	1,2-ETHANEDIOL	non-polymer		62.1	2	Chemie (EDO)
5	I, J (A, B)	water	water		18.0	661	Chemie (HOH)

Sequence modifications

A, B: 1 - 313 (UniProt: A8BGX6)

PDB	External Database	Details
Met -20	-	expression tag
Ala -19	-	expression tag
His -18	-	expression tag
His -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
Met -12	-	expression tag
Gly -11	-	expression tag
Thr -10	-	expression tag
Leu -9	-	expression tag
Glu -8	-	expression tag
Ala -7	-	expression tag
Gln -6	-	expression tag
Thr -5	-	expression tag
Gln -4	-	expression tag
Gly -3	-	expression tag
Pro -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	75598.3
Non-Polymers*	Number of molecules	6
	Total formula weight	1610.9
All*	Total formula weight	77209.3

*Water molecules are not included.