Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004032 | molecular_function | aldose reductase (NADPH) activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004032 | molecular_function | aldose reductase (NADPH) activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 34 |
| Details | BINDING SITE FOR RESIDUE NAP A 400 |
| Chain | Residue |
| A | GLY10 |
| A | TYR203 |
| A | SER204 |
| A | PRO205 |
| A | MET206 |
| A | GLY207 |
| A | GLY208 |
| A | SER209 |
| A | ASN222 |
| A | HIS242 |
| A | ILE261 |
| A | THR11 |
| A | PRO262 |
| A | LYS263 |
| A | SER264 |
| A | GLN265 |
| A | THR266 |
| A | ARG269 |
| A | ASN273 |
| A | HOH326 |
| A | HOH438 |
| A | HOH441 |
| A | TRP12 |
| A | HOH453 |
| A | HOH573 |
| A | HOH589 |
| A | HOH600 |
| A | HOH693 |
| A | ASP35 |
| A | TYR40 |
| A | HIS104 |
| A | SER155 |
| A | ASN156 |
| A | GLN177 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 401 |
| Chain | Residue |
| A | TYR38 |
| A | LYS88 |
| A | HOH649 |
| B | GLU44 |
| B | ARG48 |
| site_id | AC3 |
| Number of Residues | 33 |
| Details | BINDING SITE FOR RESIDUE NAP B 400 |
| Chain | Residue |
| B | GLY10 |
| B | THR11 |
| B | TRP12 |
| B | ASP35 |
| B | TYR40 |
| B | HIS104 |
| B | SER155 |
| B | ASN156 |
| B | GLN177 |
| B | TYR203 |
| B | SER204 |
| B | PRO205 |
| B | MET206 |
| B | GLY207 |
| B | GLY208 |
| B | SER209 |
| B | ASN222 |
| B | HIS242 |
| B | ILE261 |
| B | PRO262 |
| B | LYS263 |
| B | SER264 |
| B | GLN265 |
| B | THR266 |
| B | ARG269 |
| B | ASN273 |
| B | HOH323 |
| B | HOH362 |
| B | HOH418 |
| B | HOH447 |
| B | HOH451 |
| B | HOH496 |
| B | HOH616 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 401 |
| Chain | Residue |
| A | GLU44 |
| A | HOH457 |
| B | TYR38 |
| B | LYS88 |
Functional Information from PROSITE/UniProt
| site_id | PS00062 |
| Number of Residues | 18 |
| Details | ALDOKETO_REDUCTASE_2 Aldo/keto reductase family signature 2. MeqlveeglVKHIGVSNY |
| Chain | Residue | Details |
| A | MET140-TYR157 | |
| site_id | PS00798 |
| Number of Residues | 18 |
| Details | ALDOKETO_REDUCTASE_1 Aldo/keto reductase family signature 1. GYRHIDCAyvyqnEeaIG |
| Chain | Residue | Details |
| A | GLY30-GLY47 | |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1mrq |
| Chain | Residue | Details |
| A | HIS104 | |
| A | ASP35 | |
| A | TYR40 | |
| A | LYS71 | |
| site_id | CSA2 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1mrq |
| Chain | Residue | Details |
| B | HIS104 | |
| B | ASP35 | |
| B | TYR40 | |
| B | LYS71 | |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1mrq |
| Chain | Residue | Details |
| A | TYR40 | |
| A | LYS71 | |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1mrq |
| Chain | Residue | Details |
| B | TYR40 | |
| B | LYS71 | |
