3KQ4
Structure of Intrinsic Factor-Cobalamin bound to its receptor Cubilin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E (A, C, E) | Gastric intrinsic factor | polymer | 393 | 42815.8 | 3 | UniProt (P27352) Pfam (PF01122) | Homo sapiens (human) | Intrinsic factor, INF, IF |
| 2 | B, D, F (B, D, F) | Cubilin | polymer | 457 | 51629.1 | 3 | UniProt (O60494) Pfam (PF00431) | Homo sapiens (human) | Intrinsic factor-cobalamin receptor, Intrinsic factor-vitamin B12 receptor, 460 kDa receptor, Intestinal intrinsic factor receptor |
| 3 | G, H, J, K, M... (G, H, J, K, M...) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 6 | In PDB GlyTouCan (G22768VO) | |||
| 4 | I, L, O (I, L, O) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 3 | In PDB GlyTouCan (G42666HT) | |||
| 5 | BA, DA, EA, FA, GA... (C, D, E, A, F...) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 21 | Chemie (NAG) | |||
| 6 | CA, OA, Q (C, E, A) | COBALAMIN | non-polymer | 1330.4 | 3 | Chemie (B12) | |||
| 7 | AA, JA, KA, LA, MA... (B, D, F) | CALCIUM ION | non-polymer | 40.1 | 12 | Chemie (CA) |
Sequence modifications
A, C, E: 25 - 417 (UniProt: P27352)
| PDB | External Database | Details |
|---|---|---|
| His 91 | Gln 91 | SEE REMARK 999 |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 283334.6 | |
| Branched | Number of molecules | 9 |
| Total formula weight | 6738.1 | |
| Non-Polymers* | Number of molecules | 36 |
| Total formula weight | 9117.4 | |
| All* | Total formula weight | 299190.1 |
