3KQ4
Structure of Intrinsic Factor-Cobalamin bound to its receptor Cubilin
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005768 | cellular_component | endosome |
| A | 0005902 | cellular_component | microvillus |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006824 | biological_process | cobalt ion transport |
| A | 0015889 | biological_process | cobalamin transport |
| A | 0016324 | cellular_component | apical plasma membrane |
| A | 0031419 | molecular_function | cobalamin binding |
| A | 0043202 | cellular_component | lysosomal lumen |
| A | 0140104 | molecular_function | molecular carrier activity |
| A | 0140355 | molecular_function | cargo receptor ligand activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005576 | cellular_component | extracellular region |
| C | 0005615 | cellular_component | extracellular space |
| C | 0005768 | cellular_component | endosome |
| C | 0005902 | cellular_component | microvillus |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0006824 | biological_process | cobalt ion transport |
| C | 0015889 | biological_process | cobalamin transport |
| C | 0016324 | cellular_component | apical plasma membrane |
| C | 0031419 | molecular_function | cobalamin binding |
| C | 0043202 | cellular_component | lysosomal lumen |
| C | 0140104 | molecular_function | molecular carrier activity |
| C | 0140355 | molecular_function | cargo receptor ligand activity |
| E | 0005515 | molecular_function | protein binding |
| E | 0005576 | cellular_component | extracellular region |
| E | 0005615 | cellular_component | extracellular space |
| E | 0005768 | cellular_component | endosome |
| E | 0005902 | cellular_component | microvillus |
| E | 0006811 | biological_process | monoatomic ion transport |
| E | 0006824 | biological_process | cobalt ion transport |
| E | 0015889 | biological_process | cobalamin transport |
| E | 0016324 | cellular_component | apical plasma membrane |
| E | 0031419 | molecular_function | cobalamin binding |
| E | 0043202 | cellular_component | lysosomal lumen |
| E | 0140104 | molecular_function | molecular carrier activity |
| E | 0140355 | molecular_function | cargo receptor ligand activity |
Functional Information from PROSITE/UniProt
| site_id | PS00468 |
| Number of Residues | 14 |
| Details | COBALAMIN_BINDING Eukaryotic cobalamin-binding proteins signature. NVDTGAMAtLALTC |
| Chain | Residue | Details |
| A | ASN169-CYS182 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 9 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17954916","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20237569","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 42 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P17267","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"20237569","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 9 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 3 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"17954916","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20237569","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 330 |
| Details | Domain: {"description":"CUB 5","evidences":[{"source":"PROSITE-ProRule","id":"PRU00059","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 339 |
| Details | Domain: {"description":"CUB 6","evidences":[{"source":"PROSITE-ProRule","id":"PRU00059","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 336 |
| Details | Domain: {"description":"CUB 7","evidences":[{"source":"PROSITE-ProRule","id":"PRU00059","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 57 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"20237569","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3KQ4","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 24 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"20237569","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3KQ4","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
