3KMR

Crystal structure of RARalpha ligand binding domain in complex with an agonist ligand (Am580) and a coactivator fragment

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Retinoic acid receptor alpha	polymer	266	29967.6	1	UniProt (P10276) Pfam (PF00104) In PDB	Homo sapiens (human)	RAR-alpha, Nuclear receptor subfamily 1 group B member 1
2	C	Nuclear receptor coactivator 1	polymer	13	1591.9	1	UniProt (Q15788) In PDB		NCoA-1, Steroid receptor coactivator 1, SRC-1, RIP160, Protein Hin-2, Renal carcinoma antigen NY-REN-52
3	A	4-{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino}benzoic acid	non-polymer		351.4	1	Chemie (EQN)
4		water	water		18.0	121	Chemie (HOH)

Sequence modifications

A: 176 - 421 (UniProt: P10276)

PDB	External Database	Details
Met 156	-	expression tag
Gly 157	-	expression tag
Ser 158	-	expression tag
Ser 159	-	expression tag
His 160	-	expression tag
His 161	-	expression tag
His 162	-	expression tag
His 163	-	expression tag
His 164	-	expression tag
His 165	-	expression tag
Ser 166	-	expression tag
Ser 167	-	expression tag
Gly 168	-	expression tag
Leu 169	-	expression tag
Val 170	-	expression tag
Pro 171	-	expression tag
Arg 172	-	expression tag
Gly 173	-	expression tag
Ser 174	-	expression tag
His 175	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	31559.5
Non-Polymers*	Number of molecules	1
	Total formula weight	351.4
All*	Total formula weight	31910.9

*Water molecules are not included.