3KMR

Crystal structure of RARalpha ligand binding domain in complex with an agonist ligand (Am580) and a coactivator fragment

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0004879	molecular_function	nuclear receptor activity
A	0005634	cellular_component	nucleus
A	0006355	biological_process	regulation of DNA-templated transcription
A	0048384	biological_process	retinoic acid receptor signaling pathway

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE EQN A 1

Chain	Residue
A	HOH14
A	SER287
A	PHE302
A	GLY391
A	LEU398
A	HOH15
A	PHE228
A	LEU231
A	SER232
A	LEU269
A	ILE273
A	ARG276
A	PHE286

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
C	SER640
A	SER287

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site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Phosphoserine; by PKA => ECO:0000269|PubMed:20215566

Chain	Residue	Details
A	SER219
A	SER369

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site_id	SWS_FT_FI3
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000269|PubMed:19850744

Chain	Residue	Details
A	LYS399

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