3KFJ
Crystal Structure of the Grb2 SH2 Domain in Complex with a Flexible Ac-pY-E-N-NH2 Tripeptide Mimic
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Growth factor receptor-bound protein 2 | polymer | 117 | 13758.5 | 1 | UniProt (P62993) Pfam (PF00017) | Homo sapiens (human) | Adapter protein GRB2, SH2/SH3 adapter GRB2, Protein Ash |
| 2 | B (A) | N-{(2S)-4-(methylamino)-4-oxo-2-[4-(phosphonooxy)benzyl]butanoyl}-L-alpha-glutamyl-L-aspartamide | non-polymer | 559.5 | 1 | BIRD (PRD_000635) Chemie (YEN) | |||
| 3 | C, D (A) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 4 | E (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 5 | F (A) | water | water | 18.0 | 92 | Chemie (HOH) |
Sequence modifications
A: 53 - 163 (UniProt: P62993)
| PDB | External Database | Details |
|---|---|---|
| His 164 | - | expression tag |
| His 165 | - | expression tag |
| His 166 | - | expression tag |
| His 167 | - | expression tag |
| His 168 | - | expression tag |
| His 169 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 13758.5 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 654.7 | |
| All* | Total formula weight | 14413.2 |
