3KFJ
Crystal Structure of the Grb2 SH2 Domain in Complex with a Flexible Ac-pY-E-N-NH2 Tripeptide Mimic
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE YEN A 1 |
| Chain | Residue |
| A | HOH17 |
| A | SER96 |
| A | GLN106 |
| A | HIS107 |
| A | PHE108 |
| A | LYS109 |
| A | LEU120 |
| A | TRP121 |
| A | GLU152 |
| A | VAL154 |
| A | PRO155 |
| A | HOH22 |
| A | HOH165 |
| A | HOH28 |
| A | HOH35 |
| A | ARG67 |
| A | ARG78 |
| A | ARG86 |
| A | SER88 |
| A | SER90 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A 164 |
| Chain | Residue |
| A | ARG78 |
| A | LYS109 |
| A | GLU152 |
| A | HOH200 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL A 2 |
| Chain | Residue |
| A | HOH52 |
| A | ARG112 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG A 3 |
| Chain | Residue |
| A | SER139 |
| A | GLN145 |
| A | HOH182 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 92 |
| Details | Domain: {"description":"SH2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00191","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"34348893","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
