3K4S

The structure of the catalytic domain of human PDE4d with 4-(3-Butoxy-4-methoxyphenyl)methyl-2-imidazolidone

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	polymer	349	40096.4	1	UniProt (Q08499) Pfam (PF00233) In PDB	Homo sapiens (human)	DPDE3, PDE43
2	A	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
3	A	(4R)-4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one	non-polymer		278.3	1	Chemie (0MO)
4	A	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)
5		water	water		18.0	268	Chemie (HOH)

Sequence modifications

A: 86 - 413 (UniProt: Q08499)

PDB	External Database	Details
Met 65	-	expression tag
Gly 66	-	expression tag
Ser 67	-	expression tag
Ser 68	-	expression tag
His 69	-	expression tag
His 70	-	expression tag
His 71	-	expression tag
His 72	-	expression tag
His 73	-	expression tag
His 74	-	expression tag
Ser 75	-	expression tag
Ser 76	-	expression tag
Gly 77	-	expression tag
Leu 78	-	expression tag
Val 79	-	expression tag
Pro 80	-	expression tag
Arg 81	-	expression tag
Gly 82	-	expression tag
Ser 83	-	expression tag
His 84	-	expression tag
Met 85	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	40096.4
Non-Polymers*	Number of molecules	3
	Total formula weight	368.1
All*	Total formula weight	40464.4

*Water molecules are not included.