3JTL
Crystal structure of archaeal 20S proteasome in complex with mutated P26 activator
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Proteasome subunit alpha | polymer | 227 | 25125.6 | 7 | UniProt (P25156) Pfam (PF10584) Pfam (PF00227) | Thermoplasma acidophilum | Multicatalytic endopeptidase complex subunit alpha |
| 2 | H, I, J, K, L... (H, I, J, K, L...) | Proteasome subunit beta | polymer | 203 | 22294.8 | 7 | UniProt (P28061) Pfam (PF00227) | Thermoplasma acidophilum | Multicatalytic endopeptidase complex subunit beta |
| 3 | O, P, Q, R, S... (O, P, Q, R, S...) | Proteasome activator protein PA26 | polymer | 228 | 25117.6 | 7 | UniProt (Q9U8G2) Pfam (PF02252) | Trypanosoma brucei |
Sequence modifications
O, P, Q, R, S, T, U: 4 - 231 (UniProt: Q9U8G2)
| PDB | External Database | Details |
|---|---|---|
| Val 49 | Thr 49 | variant |
| His 225 | Gly 225 | engineered mutation |
| Leu 226 | Ser 226 | engineered mutation |
| Val 228 | His 228 | engineered mutation |
| Leu 229 | Met 229 | engineered mutation |
| Tyr 230 | Val 230 | engineered mutation |
| Arg 231 | Ser 231 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 21 |
| Total formula weight | 507766.6 | |
| All* | Total formula weight | 507766.6 |
