3JCR
3D structure determination of the human*U4/U6.U5* tri-snRNP complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | G | hPrp6 | polymer | 941 | 107092.2 | 1 | UniProt (O94906) Pfam (PF06424) Pfam (PF14559) Pfam (PF13432) In PDB | Homo sapiens (human) | Pre-mRNA-processing factor 6, Androgen receptor N-terminal domain-transactivating protein 1, ANT-1, PRP6 homolog, U5 snRNP-associated 102 kDa protein, U5-102 kDa protein |
| 2 | D | U5-40K | polymer | 357 | 39359.5 | 1 | UniProt (Q96DI7) Pfam (PF00400) In PDB | Homo sapiens (human) | U5 small nuclear ribonucleoprotein 40 kDa protein, U5 snRNP 40 kDa protein, U5-40K, 38 kDa-splicing factor, Prp8-binding protein, hPRP8BP, U5 snRNP-specific 40 kDa protein, WD repeat-containing protein 57 |
| 3 | C | hBrr2 | polymer | 2136 | 244823.4 | 1 | UniProt (O75643) Pfam (PF21188) Pfam (PF18149) Pfam (PF00270) Pfam (PF00271) Pfam (PF02889) In PDB | Homo sapiens (human) | U5 small nuclear ribonucleoprotein 200 kDa helicase, Activating signal cointegrator 1 complex subunit 3-like 1, BRR2 homolog, U5 snRNP-specific 200 kDa protein, U5-200KD |
| 4 | E | hDim1 | polymer | 142 | 16807.3 | 1 | UniProt (P83876) Pfam (PF02966) In PDB | Homo sapiens (human) | Thioredoxin-like protein 4A, DIM1 protein homolog, Spliceosomal U5 snRNP-specific 15 kDa protein, Thioredoxin-like U5 snRNP protein U5-15kD |
| 5 | A | hPrp8 | polymer | 2335 | 273974.3 | 1 | UniProt (Q6P2Q9) Pfam (PF10598) Pfam (PF10597) Pfam (PF10596) Pfam (PF12134) Pfam (PF01398) Pfam (PF08084) Pfam (PF08082) Pfam (PF08083) In PDB | Homo sapiens (human) | Pre-mRNA-processing-splicing factor 8, 220 kDa U5 snRNP-specific protein, PRP8 homolog, Splicing factor Prp8, p220 |
| 6 | F | hPrp28 | polymer | 820 | 95785.1 | 1 | UniProt (Q9BUQ8) Pfam (PF00270) Pfam (PF00271) In PDB | Homo sapiens (human) | Probable ATP-dependent RNA helicase DDX23, 100 kDa U5 snRNP-specific protein, DEAD box protein 23, PRP28 homolog, U5-100kD |
| 7 | B | hSnu114 | polymer | 972 | 109560.6 | 1 | UniProt (Q15029) Pfam (PF16004) Pfam (PF00009) Pfam (PF03144) Pfam (PF14492) Pfam (PF03764) Pfam (PF00679) In PDB | Homo sapiens (human) | 116 kDa U5 small nuclear ribonucleoprotein component, Elongation factor Tu GTP-binding domain-containing protein 2, SNU114 homolog, hSNU114, U5 snRNP-specific protein, 116 kDa, U5-116 kDa |
| 8 | O, o | SmB | polymer | 240 | 24642.1 | 2 | UniProt (P14678) Pfam (PF01423) In PDB | Homo sapiens (human) | Small nuclear ribonucleoprotein-associated proteins B and B', snRNP-B, Sm protein B/B', Sm-B/B', SmB/B' |
| 9 | P, p | SmD1 | polymer | 119 | 13310.7 | 2 | UniProt (P62314) Pfam (PF01423) In PDB | Homo sapiens (human) | Small nuclear ribonucleoprotein Sm D1, Sm-D1, Sm-D autoantigen, snRNP core protein D1 |
| 10 | Q, q | SmD2 | polymer | 118 | 13551.9 | 2 | UniProt (P62316) Pfam (PF01423) In PDB | Homo sapiens (human) | Small nuclear ribonucleoprotein Sm D2, Sm-D2, snRNP core protein D2 |
| 11 | R, r | SmD3 | polymer | 126 | 13940.3 | 2 | UniProt (P62318) Pfam (PF01423) In PDB | Homo sapiens (human) | Small nuclear ribonucleoprotein Sm D3, Sm-D3, snRNP core protein D3 |
| 12 | S, s | SmE | polymer | 92 | 10817.6 | 2 | UniProt (P62304) Pfam (PF01423) In PDB | Homo sapiens (human) | Small nuclear ribonucleoprotein E, snRNP-E, Sm protein E, Sm-E, SmE |
| 13 | T, t | SmF | polymer | 86 | 9734.2 | 2 | UniProt (P62306) Pfam (PF01423) In PDB | Homo sapiens (human) | Small nuclear ribonucleoprotein F, snRNP-F, Sm protein F, Sm-F, SmF |
| 14 | U, u | SmG | polymer | 76 | 8508.1 | 2 | UniProt (P62308) Pfam (PF01423) In PDB | Homo sapiens (human) | Small nuclear ribonucleoprotein G, snRNP-G, Sm protein G, Sm-G, SmG |
| 15 | 8 | LSm8 | polymer | 96 | 10410.6 | 1 | UniProt (O95777) Pfam (PF01423) In PDB | Homo sapiens (human) | U6 snRNA-associated Sm-like protein LSm8 |
| 16 | 6 | LSm6 | polymer | 80 | 9139.6 | 1 | UniProt (P62312) Pfam (PF01423) In PDB | Homo sapiens (human) | U6 snRNA-associated Sm-like protein LSm6 |
| 17 | 5 | LSm5 | polymer | 91 | 9945.4 | 1 | UniProt (Q9Y4Y9) Pfam (PF01423) In PDB | Homo sapiens (human) | U6 snRNA-associated Sm-like protein LSm5 |
| 18 | 4 | LSm4 | polymer | 139 | 15375.8 | 1 | UniProt (Q9Y4Z0) Pfam (PF01423) In PDB | Homo sapiens (human) | U6 snRNA-associated Sm-like protein LSm4, Glycine-rich protein, GRP |
| 19 | 3 | LSm3 | polymer | 102 | 11859.4 | 1 | UniProt (P62310) Pfam (PF01423) In PDB | Homo sapiens (human) | U6 snRNA-associated Sm-like protein LSm3 |
| 20 | 2 | LSm2 | polymer | 95 | 10847.5 | 1 | UniProt (Q9Y333) Pfam (PF01423) In PDB | Homo sapiens (human) | U6 snRNA-associated Sm-like protein LSm2, Protein G7b, Small nuclear ribonuclear protein D homolog, snRNP core Sm-like protein Sm-x5 |
| 21 | 7 | LSm7 | polymer | 103 | 11617.4 | 1 | UniProt (Q9UK45) Pfam (PF01423) In PDB | Homo sapiens (human) | U6 snRNA-associated Sm-like protein LSm7 |
| 22 | K | hPrp3 | polymer | 683 | 77669.2 | 1 | UniProt (O43395) Pfam (PF01480) Pfam (PF08572) Pfam (PF06544) In PDB | Homo sapiens (human) | U4/U6 small nuclear ribonucleoprotein Prp3, Pre-mRNA-splicing factor 3, hPrp3, U4/U6 snRNP 90 kDa protein |
| 23 | L | hPrp4 | polymer | 521 | 58408.0 | 1 | UniProt (Q5T1M7) Pfam (PF08799) Pfam (PF00400) UniProt (by SIFTS) (O43172) In PDB | Homo sapiens (human) | 60 kDa U4/U6 snRNP-specific spliceosomal protein, PRP4 pre-mRNA processing factor 4 homolog (Yeast), isoform CRA_b |
| 24 | J | hPrp31 | polymer | 499 | 55529.0 | 1 | UniProt (Q8WWY3) Pfam (PF01798) Pfam (PF09785) In PDB | Homo sapiens (human) | U4/U6 small nuclear ribonucleoprotein Prp31, Pre-mRNA-processing factor 31, Serologically defined breast cancer antigen NY-BR-99, U4/U6 snRNP 61 kDa protein, Protein 61K, hPrp31 |
| 25 | I | hSnu13 | polymer | 128 | 14191.5 | 1 | UniProt (P55769) Pfam (PF01248) In PDB | Homo sapiens (human) | NHP2-like protein 1, High mobility group-like nuclear protein 2 homolog 1, OTK27, SNU13 homolog, hSNU13, U4/U6.U5 small nuclear ribonucleoprotein SNU13, U4/U6.U5 tri-snRNP 15.5 kDa protein, NHP2-like protein 1, N-terminally processed |
| 26 | V | hSad1 | polymer | 565 | 65481.4 | 1 | UniProt (Q53GS9) Pfam (PF02148) Pfam (PF00443) In PDB | Homo sapiens (human) | U4/U6.U5 tri-snRNP-associated protein 2, Inactive ubiquitin-specific peptidase 39, SAD1 homolog, U4/U6.U5 tri-snRNP-associated 65 kDa protein, 65K |
| 27 | M | U4 snRNA | polymer | 145 | 46536.5 | 1 | Homo sapiens (human) | ||
| 28 | N | U6 snRNA | polymer | 106 | 34098.3 | 1 | Homo sapiens (human) | ||
| 29 | H | U5 snRNA | polymer | 116 | 36891.7 | 1 | Homo sapiens (human) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 36 |
| Total formula weight | 1544413.4 | |
| All* | Total formula weight | 1544413.4 |
