3JCR

3D structure determination of the human*U4/U6.U5* tri-snRNP complex

Functional Information from GO Data

Chain	GOid	namespace	contents
2	0000244	biological_process	spliceosomal tri-snRNP complex assembly
2	0000290	biological_process	deadenylation-dependent decapping of nuclear-transcribed mRNA
2	0000387	biological_process	spliceosomal snRNP assembly
2	0000398	biological_process	mRNA splicing, via spliceosome
2	0000932	cellular_component	P-body
2	0003723	molecular_function	RNA binding
2	0005634	cellular_component	nucleus
2	0005654	cellular_component	nucleoplasm
2	0005681	cellular_component	spliceosomal complex
2	0005688	cellular_component	U6 snRNP
2	0005737	cellular_component	cytoplasm
2	0005829	cellular_component	cytosol
2	0006397	biological_process	mRNA processing
2	0006402	biological_process	mRNA catabolic process
2	0008380	biological_process	RNA splicing
2	0017070	molecular_function	U6 snRNA binding
2	0031267	molecular_function	small GTPase binding
2	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
2	0071005	cellular_component	U2-type precatalytic spliceosome
2	0071011	cellular_component	precatalytic spliceosome
2	0071013	cellular_component	catalytic step 2 spliceosome
2	0120115	cellular_component	Lsm2-8 complex
2	1990726	cellular_component	Lsm1-7-Pat1 complex
2	1990904	cellular_component	ribonucleoprotein complex
3	0000244	biological_process	spliceosomal tri-snRNP complex assembly
3	0000290	biological_process	deadenylation-dependent decapping of nuclear-transcribed mRNA
3	0000387	biological_process	spliceosomal snRNP assembly
3	0000398	biological_process	mRNA splicing, via spliceosome
3	0000932	cellular_component	P-body
3	0003723	molecular_function	RNA binding
3	0005515	molecular_function	protein binding
3	0005634	cellular_component	nucleus
3	0005654	cellular_component	nucleoplasm
3	0005681	cellular_component	spliceosomal complex
3	0005688	cellular_component	U6 snRNP
3	0005737	cellular_component	cytoplasm
3	0005829	cellular_component	cytosol
3	0006397	biological_process	mRNA processing
3	0008380	biological_process	RNA splicing
3	0030629	molecular_function	U6 snRNA 3'-end binding
3	0033962	biological_process	P-body assembly
3	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
3	0071005	cellular_component	U2-type precatalytic spliceosome
3	0071011	cellular_component	precatalytic spliceosome
3	0071013	cellular_component	catalytic step 2 spliceosome
3	0120115	cellular_component	Lsm2-8 complex
3	1990726	cellular_component	Lsm1-7-Pat1 complex
3	1990904	cellular_component	ribonucleoprotein complex
4	0000244	biological_process	spliceosomal tri-snRNP complex assembly
4	0000290	biological_process	deadenylation-dependent decapping of nuclear-transcribed mRNA
4	0000387	biological_process	spliceosomal snRNP assembly
4	0000398	biological_process	mRNA splicing, via spliceosome
4	0000932	cellular_component	P-body
4	0000956	biological_process	nuclear-transcribed mRNA catabolic process
4	0003723	molecular_function	RNA binding
4	0005515	molecular_function	protein binding
4	0005634	cellular_component	nucleus
4	0005654	cellular_component	nucleoplasm
4	0005681	cellular_component	spliceosomal complex
4	0005688	cellular_component	U6 snRNP
4	0005737	cellular_component	cytoplasm
4	0005829	cellular_component	cytosol
4	0006396	biological_process	RNA processing
4	0006397	biological_process	mRNA processing
4	0008380	biological_process	RNA splicing
4	0016020	cellular_component	membrane
4	0017070	molecular_function	U6 snRNA binding
4	0032991	cellular_component	protein-containing complex
4	0033962	biological_process	P-body assembly
4	0042731	molecular_function	PH domain binding
4	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
4	0071005	cellular_component	U2-type precatalytic spliceosome
4	0097526	cellular_component	spliceosomal tri-snRNP complex
4	0120115	cellular_component	Lsm2-8 complex
4	1990904	cellular_component	ribonucleoprotein complex
5	0000244	biological_process	spliceosomal tri-snRNP complex assembly
5	0000290	biological_process	deadenylation-dependent decapping of nuclear-transcribed mRNA
5	0000387	biological_process	spliceosomal snRNP assembly
5	0000398	biological_process	mRNA splicing, via spliceosome
5	0003723	molecular_function	RNA binding
5	0005634	cellular_component	nucleus
5	0005654	cellular_component	nucleoplasm
5	0005681	cellular_component	spliceosomal complex
5	0005688	cellular_component	U6 snRNP
5	0005737	cellular_component	cytoplasm
5	0005829	cellular_component	cytosol
5	0006397	biological_process	mRNA processing
5	0006402	biological_process	mRNA catabolic process
5	0008380	biological_process	RNA splicing
5	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
5	0046982	molecular_function	protein heterodimerization activity
5	0071005	cellular_component	U2-type precatalytic spliceosome
5	0120115	cellular_component	Lsm2-8 complex
5	1990726	cellular_component	Lsm1-7-Pat1 complex
5	1990904	cellular_component	ribonucleoprotein complex
6	0000244	biological_process	spliceosomal tri-snRNP complex assembly
6	0000290	biological_process	deadenylation-dependent decapping of nuclear-transcribed mRNA
6	0000387	biological_process	spliceosomal snRNP assembly
6	0000398	biological_process	mRNA splicing, via spliceosome
6	0000932	cellular_component	P-body
6	0003723	molecular_function	RNA binding
6	0005515	molecular_function	protein binding
6	0005634	cellular_component	nucleus
6	0005654	cellular_component	nucleoplasm
6	0005681	cellular_component	spliceosomal complex
6	0005688	cellular_component	U6 snRNP
6	0005730	cellular_component	nucleolus
6	0005732	cellular_component	sno(s)RNA-containing ribonucleoprotein complex
6	0005737	cellular_component	cytoplasm
6	0005829	cellular_component	cytosol
6	0006364	biological_process	rRNA processing
6	0006397	biological_process	mRNA processing
6	0006402	biological_process	mRNA catabolic process
6	0008033	biological_process	tRNA processing
6	0008380	biological_process	RNA splicing
6	0030490	biological_process	maturation of SSU-rRNA
6	0030532	cellular_component	small nuclear ribonucleoprotein complex
6	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
6	0046982	molecular_function	protein heterodimerization activity
6	0071005	cellular_component	U2-type precatalytic spliceosome
6	0120115	cellular_component	Lsm2-8 complex
6	1990904	cellular_component	ribonucleoprotein complex
7	0000244	biological_process	spliceosomal tri-snRNP complex assembly
7	0000290	biological_process	deadenylation-dependent decapping of nuclear-transcribed mRNA
7	0000387	biological_process	spliceosomal snRNP assembly
7	0000398	biological_process	mRNA splicing, via spliceosome
7	0000956	biological_process	nuclear-transcribed mRNA catabolic process
7	0003723	molecular_function	RNA binding
7	0005515	molecular_function	protein binding
7	0005634	cellular_component	nucleus
7	0005654	cellular_component	nucleoplasm
7	0005681	cellular_component	spliceosomal complex
7	0005688	cellular_component	U6 snRNP
7	0005689	cellular_component	U12-type spliceosomal complex
7	0005737	cellular_component	cytoplasm
7	0005829	cellular_component	cytosol
7	0006397	biological_process	mRNA processing
7	0008380	biological_process	RNA splicing
7	0017070	molecular_function	U6 snRNA binding
7	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
7	0071004	cellular_component	U2-type prespliceosome
7	0071005	cellular_component	U2-type precatalytic spliceosome
7	0071013	cellular_component	catalytic step 2 spliceosome
7	0097526	cellular_component	spliceosomal tri-snRNP complex
7	0120115	cellular_component	Lsm2-8 complex
7	1990726	cellular_component	Lsm1-7-Pat1 complex
7	1990904	cellular_component	ribonucleoprotein complex
8	0000244	biological_process	spliceosomal tri-snRNP complex assembly
8	0000387	biological_process	spliceosomal snRNP assembly
8	0000398	biological_process	mRNA splicing, via spliceosome
8	0003723	molecular_function	RNA binding
8	0003729	molecular_function	mRNA binding
8	0005515	molecular_function	protein binding
8	0005634	cellular_component	nucleus
8	0005654	cellular_component	nucleoplasm
8	0005681	cellular_component	spliceosomal complex
8	0005688	cellular_component	U6 snRNP
8	0006397	biological_process	mRNA processing
8	0008380	biological_process	RNA splicing
8	0017070	molecular_function	U6 snRNA binding
8	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
8	0071005	cellular_component	U2-type precatalytic spliceosome
8	0071011	cellular_component	precatalytic spliceosome
8	0120115	cellular_component	Lsm2-8 complex
8	1990904	cellular_component	ribonucleoprotein complex
A	0000244	biological_process	spliceosomal tri-snRNP complex assembly
A	0000375	biological_process	RNA splicing, via transesterification reactions
A	0000387	biological_process	spliceosomal snRNP assembly
A	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
A	0000398	biological_process	mRNA splicing, via spliceosome
A	0003723	molecular_function	RNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005681	cellular_component	spliceosomal complex
A	0005682	cellular_component	U5 snRNP
A	0006397	biological_process	mRNA processing
A	0008233	molecular_function	peptidase activity
A	0008237	molecular_function	metallopeptidase activity
A	0008380	biological_process	RNA splicing
A	0016020	cellular_component	membrane
A	0016607	cellular_component	nuclear speck
A	0017070	molecular_function	U6 snRNA binding
A	0030532	cellular_component	small nuclear ribonucleoprotein complex
A	0030619	molecular_function	U1 snRNA binding
A	0030620	molecular_function	U2 snRNA binding
A	0030623	molecular_function	U5 snRNA binding
A	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
A	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
A	0070530	molecular_function	K63-linked polyubiquitin modification-dependent protein binding
A	0071005	cellular_component	U2-type precatalytic spliceosome
A	0071006	cellular_component	U2-type catalytic step 1 spliceosome
A	0071007	cellular_component	U2-type catalytic step 2 spliceosome
A	0071013	cellular_component	catalytic step 2 spliceosome
A	0071222	biological_process	cellular response to lipopolysaccharide
A	0071356	biological_process	cellular response to tumor necrosis factor
A	0097157	molecular_function	pre-mRNA intronic binding
A	0140492	molecular_function	metal-dependent deubiquitinase activity
A	1990904	cellular_component	ribonucleoprotein complex
B	0000166	molecular_function	nucleotide binding
B	0000244	biological_process	spliceosomal tri-snRNP complex assembly
B	0000387	biological_process	spliceosomal snRNP assembly
B	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
B	0000398	biological_process	mRNA splicing, via spliceosome
B	0003723	molecular_function	RNA binding
B	0003924	molecular_function	GTPase activity
B	0005515	molecular_function	protein binding
B	0005525	molecular_function	GTP binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005681	cellular_component	spliceosomal complex
B	0005829	cellular_component	cytosol
B	0006397	biological_process	mRNA processing
B	0008380	biological_process	RNA splicing
B	0015030	cellular_component	Cajal body
B	0016020	cellular_component	membrane
B	0016607	cellular_component	nuclear speck
B	0030623	molecular_function	U5 snRNA binding
B	0042220	biological_process	response to cocaine
B	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
B	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
B	0071005	cellular_component	U2-type precatalytic spliceosome
B	0071007	cellular_component	U2-type catalytic step 2 spliceosome
B	0071013	cellular_component	catalytic step 2 spliceosome
B	0071466	biological_process	cellular response to xenobiotic stimulus
C	0000166	molecular_function	nucleotide binding
C	0000244	biological_process	spliceosomal tri-snRNP complex assembly
C	0000354	biological_process	cis assembly of pre-catalytic spliceosome
C	0000387	biological_process	spliceosomal snRNP assembly
C	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
C	0000398	biological_process	mRNA splicing, via spliceosome
C	0001649	biological_process	osteoblast differentiation
C	0003676	molecular_function	nucleic acid binding
C	0003723	molecular_function	RNA binding
C	0003724	molecular_function	RNA helicase activity
C	0004386	molecular_function	helicase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005681	cellular_component	spliceosomal complex
C	0005682	cellular_component	U5 snRNP
C	0006397	biological_process	mRNA processing
C	0008380	biological_process	RNA splicing
C	0016020	cellular_component	membrane
C	0016787	molecular_function	hydrolase activity
C	0016887	molecular_function	ATP hydrolysis activity
C	0030532	cellular_component	small nuclear ribonucleoprotein complex
C	0042802	molecular_function	identical protein binding
C	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
C	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
C	0071005	cellular_component	U2-type precatalytic spliceosome
C	0071006	cellular_component	U2-type catalytic step 1 spliceosome
C	0071013	cellular_component	catalytic step 2 spliceosome
D	0000244	biological_process	spliceosomal tri-snRNP complex assembly
D	0000375	biological_process	RNA splicing, via transesterification reactions
D	0000387	biological_process	spliceosomal snRNP assembly
D	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
D	0000398	biological_process	mRNA splicing, via spliceosome
D	0003723	molecular_function	RNA binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005681	cellular_component	spliceosomal complex
D	0005682	cellular_component	U5 snRNP
D	0005732	cellular_component	sno(s)RNA-containing ribonucleoprotein complex
D	0006396	biological_process	RNA processing
D	0006397	biological_process	mRNA processing
D	0008380	biological_process	RNA splicing
D	0016607	cellular_component	nuclear speck
D	0071007	cellular_component	U2-type catalytic step 2 spliceosome
D	0071013	cellular_component	catalytic step 2 spliceosome
E	0000245	biological_process	spliceosomal complex assembly
E	0000375	biological_process	RNA splicing, via transesterification reactions
E	0000387	biological_process	spliceosomal snRNP assembly
E	0000398	biological_process	mRNA splicing, via spliceosome
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005681	cellular_component	spliceosomal complex
E	0005682	cellular_component	U5 snRNP
E	0006397	biological_process	mRNA processing
E	0008380	biological_process	RNA splicing
E	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
E	0051301	biological_process	cell division
E	0071005	cellular_component	U2-type precatalytic spliceosome
F	0000166	molecular_function	nucleotide binding
F	0000244	biological_process	spliceosomal tri-snRNP complex assembly
F	0000354	biological_process	cis assembly of pre-catalytic spliceosome
F	0000375	biological_process	RNA splicing, via transesterification reactions
F	0000387	biological_process	spliceosomal snRNP assembly
F	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
F	0000398	biological_process	mRNA splicing, via spliceosome
F	0000785	cellular_component	chromatin
F	0003676	molecular_function	nucleic acid binding
F	0003723	molecular_function	RNA binding
F	0003724	molecular_function	RNA helicase activity
F	0003729	molecular_function	mRNA binding
F	0004386	molecular_function	helicase activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005681	cellular_component	spliceosomal complex
F	0005682	cellular_component	U5 snRNP
F	0005694	cellular_component	chromosome
F	0005730	cellular_component	nucleolus
F	0006397	biological_process	mRNA processing
F	0008380	biological_process	RNA splicing
F	0016787	molecular_function	hydrolase activity
F	0016887	molecular_function	ATP hydrolysis activity
F	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
F	0062176	biological_process	R-loop processing
F	0070062	cellular_component	extracellular exosome
F	0071013	cellular_component	catalytic step 2 spliceosome
G	0000244	biological_process	spliceosomal tri-snRNP complex assembly
G	0000245	biological_process	spliceosomal complex assembly
G	0000375	biological_process	RNA splicing, via transesterification reactions
G	0000387	biological_process	spliceosomal snRNP assembly
G	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
G	0000398	biological_process	mRNA splicing, via spliceosome
G	0003723	molecular_function	RNA binding
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005681	cellular_component	spliceosomal complex
G	0005682	cellular_component	U5 snRNP
G	0006396	biological_process	RNA processing
G	0006397	biological_process	mRNA processing
G	0006403	biological_process	RNA localization
G	0008380	biological_process	RNA splicing
G	0016020	cellular_component	membrane
G	0016607	cellular_component	nuclear speck
G	0030674	molecular_function	protein-macromolecule adaptor activity
G	0042802	molecular_function	identical protein binding
G	0043021	molecular_function	ribonucleoprotein complex binding
G	0045944	biological_process	positive regulation of transcription by RNA polymerase II
G	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
G	0071005	cellular_component	U2-type precatalytic spliceosome
G	0071013	cellular_component	catalytic step 2 spliceosome
I	0000244	biological_process	spliceosomal tri-snRNP complex assembly
I	0000245	biological_process	spliceosomal complex assembly
I	0000387	biological_process	spliceosomal snRNP assembly
I	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
I	0000398	biological_process	mRNA splicing, via spliceosome
I	0000451	biological_process	rRNA 2'-O-methylation
I	0000492	biological_process	box C/D snoRNP assembly
I	0001651	cellular_component	dense fibrillar component
I	0003723	molecular_function	RNA binding
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005681	cellular_component	spliceosomal complex
I	0005690	cellular_component	U4atac snRNP
I	0005730	cellular_component	nucleolus
I	0006397	biological_process	mRNA processing
I	0008380	biological_process	RNA splicing
I	0016556	biological_process	mRNA modification
I	0030182	biological_process	neuron differentiation
I	0030490	biological_process	maturation of SSU-rRNA
I	0030515	molecular_function	snoRNA binding
I	0030621	molecular_function	U4 snRNA binding
I	0030622	molecular_function	U4atac snRNA binding
I	0031428	cellular_component	box C/D methylation guide snoRNP complex
I	0032040	cellular_component	small-subunit processome
I	0032991	cellular_component	protein-containing complex
I	0034511	molecular_function	U3 snoRNA binding
I	0034512	molecular_function	box C/D sno(s)RNA binding
I	0042254	biological_process	ribosome biogenesis
I	0042274	biological_process	ribosomal small subunit biogenesis
I	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
I	0051117	molecular_function	ATPase binding
I	0071005	cellular_component	U2-type precatalytic spliceosome
I	0071011	cellular_component	precatalytic spliceosome
I	1990904	cellular_component	ribonucleoprotein complex
J	0000244	biological_process	spliceosomal tri-snRNP complex assembly
J	0000387	biological_process	spliceosomal snRNP assembly
J	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
J	0000398	biological_process	mRNA splicing, via spliceosome
J	0003723	molecular_function	RNA binding
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005681	cellular_component	spliceosomal complex
J	0005684	cellular_component	U2-type spliceosomal complex
J	0005687	cellular_component	U4 snRNP
J	0005690	cellular_component	U4atac snRNP
J	0006397	biological_process	mRNA processing
J	0008380	biological_process	RNA splicing
J	0015030	cellular_component	Cajal body
J	0016607	cellular_component	nuclear speck
J	0030621	molecular_function	U4 snRNA binding
J	0030622	molecular_function	U4atac snRNA binding
J	0030674	molecular_function	protein-macromolecule adaptor activity
J	0042802	molecular_function	identical protein binding
J	0043021	molecular_function	ribonucleoprotein complex binding
J	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
J	0048254	biological_process	snoRNA localization
J	0070990	molecular_function	snRNP binding
J	0071005	cellular_component	U2-type precatalytic spliceosome
J	0071011	cellular_component	precatalytic spliceosome
J	0071166	biological_process	ribonucleoprotein complex localization
J	0071339	cellular_component	MLL1 complex
J	0097526	cellular_component	spliceosomal tri-snRNP complex
J	1990904	cellular_component	ribonucleoprotein complex
K	0000244	biological_process	spliceosomal tri-snRNP complex assembly
K	0000245	biological_process	spliceosomal complex assembly
K	0000375	biological_process	RNA splicing, via transesterification reactions
K	0000387	biological_process	spliceosomal snRNP assembly
K	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
K	0000398	biological_process	mRNA splicing, via spliceosome
K	0003723	molecular_function	RNA binding
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005681	cellular_component	spliceosomal complex
K	0006397	biological_process	mRNA processing
K	0008380	biological_process	RNA splicing
K	0015030	cellular_component	Cajal body
K	0016607	cellular_component	nuclear speck
K	0032991	cellular_component	protein-containing complex
K	0042802	molecular_function	identical protein binding
K	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
K	0071005	cellular_component	U2-type precatalytic spliceosome
L	0000244	biological_process	spliceosomal tri-snRNP complex assembly
L	0000245	biological_process	spliceosomal complex assembly
L	0000375	biological_process	RNA splicing, via transesterification reactions
L	0000387	biological_process	spliceosomal snRNP assembly
L	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
L	0000398	biological_process	mRNA splicing, via spliceosome
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005681	cellular_component	spliceosomal complex
L	0006396	biological_process	RNA processing
L	0006397	biological_process	mRNA processing
L	0008380	biological_process	RNA splicing
L	0015030	cellular_component	Cajal body
L	0016607	cellular_component	nuclear speck
L	0017070	molecular_function	U6 snRNA binding
L	0030621	molecular_function	U4 snRNA binding
L	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
L	0071001	cellular_component	U4/U6 snRNP
L	0071005	cellular_component	U2-type precatalytic spliceosome
L	0097525	cellular_component	spliceosomal snRNP complex
o	0000244	biological_process	spliceosomal tri-snRNP complex assembly
o	0000245	biological_process	spliceosomal complex assembly
o	0000387	biological_process	spliceosomal snRNP assembly
o	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
o	0000398	biological_process	mRNA splicing, via spliceosome
o	0003723	molecular_function	RNA binding
o	0005515	molecular_function	protein binding
o	0005634	cellular_component	nucleus
o	0005654	cellular_component	nucleoplasm
o	0005681	cellular_component	spliceosomal complex
o	0005682	cellular_component	U5 snRNP
o	0005683	cellular_component	U7 snRNP
o	0005684	cellular_component	U2-type spliceosomal complex
o	0005685	cellular_component	U1 snRNP
o	0005686	cellular_component	U2 snRNP
o	0005687	cellular_component	U4 snRNP
o	0005689	cellular_component	U12-type spliceosomal complex
o	0005697	cellular_component	telomerase holoenzyme complex
o	0005737	cellular_component	cytoplasm
o	0005829	cellular_component	cytosol
o	0006397	biological_process	mRNA processing
o	0006479	biological_process	protein methylation
o	0008380	biological_process	RNA splicing
o	0030532	cellular_component	small nuclear ribonucleoprotein complex
o	0034709	cellular_component	methylosome
o	0034719	cellular_component	SMN-Sm protein complex
o	0036261	biological_process	7-methylguanosine cap hypermethylation
o	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
o	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
o	0070034	molecular_function	telomerase RNA binding
o	0070990	molecular_function	snRNP binding
o	0071004	cellular_component	U2-type prespliceosome
o	0071005	cellular_component	U2-type precatalytic spliceosome
o	0071007	cellular_component	U2-type catalytic step 2 spliceosome
o	0071013	cellular_component	catalytic step 2 spliceosome
o	0071045	biological_process	nuclear histone mRNA catabolic process
o	0071204	cellular_component	histone pre-mRNA 3'end processing complex
o	0071208	molecular_function	histone pre-mRNA DCP binding
o	1903241	biological_process	U2-type prespliceosome assembly
o	1990446	molecular_function	U1 snRNP binding
o	1990447	molecular_function	U2 snRNP binding
o	1990904	cellular_component	ribonucleoprotein complex
O	0000244	biological_process	spliceosomal tri-snRNP complex assembly
O	0000245	biological_process	spliceosomal complex assembly
O	0000387	biological_process	spliceosomal snRNP assembly
O	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
O	0000398	biological_process	mRNA splicing, via spliceosome
O	0003723	molecular_function	RNA binding
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005681	cellular_component	spliceosomal complex
O	0005682	cellular_component	U5 snRNP
O	0005683	cellular_component	U7 snRNP
O	0005684	cellular_component	U2-type spliceosomal complex
O	0005685	cellular_component	U1 snRNP
O	0005686	cellular_component	U2 snRNP
O	0005687	cellular_component	U4 snRNP
O	0005689	cellular_component	U12-type spliceosomal complex
O	0005697	cellular_component	telomerase holoenzyme complex
O	0005737	cellular_component	cytoplasm
O	0005829	cellular_component	cytosol
O	0006397	biological_process	mRNA processing
O	0006479	biological_process	protein methylation
O	0008380	biological_process	RNA splicing
O	0030532	cellular_component	small nuclear ribonucleoprotein complex
O	0034709	cellular_component	methylosome
O	0034719	cellular_component	SMN-Sm protein complex
O	0036261	biological_process	7-methylguanosine cap hypermethylation
O	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
O	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
O	0070034	molecular_function	telomerase RNA binding
O	0070990	molecular_function	snRNP binding
O	0071004	cellular_component	U2-type prespliceosome
O	0071005	cellular_component	U2-type precatalytic spliceosome
O	0071007	cellular_component	U2-type catalytic step 2 spliceosome
O	0071013	cellular_component	catalytic step 2 spliceosome
O	0071045	biological_process	nuclear histone mRNA catabolic process
O	0071204	cellular_component	histone pre-mRNA 3'end processing complex
O	0071208	molecular_function	histone pre-mRNA DCP binding
O	1903241	biological_process	U2-type prespliceosome assembly
O	1990446	molecular_function	U1 snRNP binding
O	1990447	molecular_function	U2 snRNP binding
O	1990904	cellular_component	ribonucleoprotein complex
p	0000243	cellular_component	commitment complex
p	0000244	biological_process	spliceosomal tri-snRNP complex assembly
p	0000245	biological_process	spliceosomal complex assembly
p	0000387	biological_process	spliceosomal snRNP assembly
p	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
p	0000398	biological_process	mRNA splicing, via spliceosome
p	0003723	molecular_function	RNA binding
p	0005515	molecular_function	protein binding
p	0005634	cellular_component	nucleus
p	0005654	cellular_component	nucleoplasm
p	0005681	cellular_component	spliceosomal complex
p	0005682	cellular_component	U5 snRNP
p	0005684	cellular_component	U2-type spliceosomal complex
p	0005685	cellular_component	U1 snRNP
p	0005686	cellular_component	U2 snRNP
p	0005687	cellular_component	U4 snRNP
p	0005689	cellular_component	U12-type spliceosomal complex
p	0005737	cellular_component	cytoplasm
p	0005829	cellular_component	cytosol
p	0006396	biological_process	RNA processing
p	0006397	biological_process	mRNA processing
p	0008380	biological_process	RNA splicing
p	0030532	cellular_component	small nuclear ribonucleoprotein complex
p	0034709	cellular_component	methylosome
p	0034715	cellular_component	pICln-Sm protein complex
p	0034719	cellular_component	SMN-Sm protein complex
p	0036261	biological_process	7-methylguanosine cap hypermethylation
p	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
p	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
p	0071005	cellular_component	U2-type precatalytic spliceosome
p	0071007	cellular_component	U2-type catalytic step 2 spliceosome
p	0071011	cellular_component	precatalytic spliceosome
p	0071013	cellular_component	catalytic step 2 spliceosome
p	0097526	cellular_component	spliceosomal tri-snRNP complex
p	1903241	biological_process	U2-type prespliceosome assembly
p	1990446	molecular_function	U1 snRNP binding
p	1990904	cellular_component	ribonucleoprotein complex
P	0000243	cellular_component	commitment complex
P	0000244	biological_process	spliceosomal tri-snRNP complex assembly
P	0000245	biological_process	spliceosomal complex assembly
P	0000387	biological_process	spliceosomal snRNP assembly
P	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
P	0000398	biological_process	mRNA splicing, via spliceosome
P	0003723	molecular_function	RNA binding
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0005681	cellular_component	spliceosomal complex
P	0005682	cellular_component	U5 snRNP
P	0005684	cellular_component	U2-type spliceosomal complex
P	0005685	cellular_component	U1 snRNP
P	0005686	cellular_component	U2 snRNP
P	0005687	cellular_component	U4 snRNP
P	0005689	cellular_component	U12-type spliceosomal complex
P	0005737	cellular_component	cytoplasm
P	0005829	cellular_component	cytosol
P	0006396	biological_process	RNA processing
P	0006397	biological_process	mRNA processing
P	0008380	biological_process	RNA splicing
P	0030532	cellular_component	small nuclear ribonucleoprotein complex
P	0034709	cellular_component	methylosome
P	0034715	cellular_component	pICln-Sm protein complex
P	0034719	cellular_component	SMN-Sm protein complex
P	0036261	biological_process	7-methylguanosine cap hypermethylation
P	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
P	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
P	0071005	cellular_component	U2-type precatalytic spliceosome
P	0071007	cellular_component	U2-type catalytic step 2 spliceosome
P	0071011	cellular_component	precatalytic spliceosome
P	0071013	cellular_component	catalytic step 2 spliceosome
P	0097526	cellular_component	spliceosomal tri-snRNP complex
P	1903241	biological_process	U2-type prespliceosome assembly
P	1990446	molecular_function	U1 snRNP binding
P	1990904	cellular_component	ribonucleoprotein complex
q	0000244	biological_process	spliceosomal tri-snRNP complex assembly
q	0000245	biological_process	spliceosomal complex assembly
q	0000387	biological_process	spliceosomal snRNP assembly
q	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
q	0000398	biological_process	mRNA splicing, via spliceosome
q	0003723	molecular_function	RNA binding
q	0005515	molecular_function	protein binding
q	0005634	cellular_component	nucleus
q	0005654	cellular_component	nucleoplasm
q	0005681	cellular_component	spliceosomal complex
q	0005682	cellular_component	U5 snRNP
q	0005684	cellular_component	U2-type spliceosomal complex
q	0005685	cellular_component	U1 snRNP
q	0005686	cellular_component	U2 snRNP
q	0005687	cellular_component	U4 snRNP
q	0005689	cellular_component	U12-type spliceosomal complex
q	0005829	cellular_component	cytosol
q	0006397	biological_process	mRNA processing
q	0008380	biological_process	RNA splicing
q	0030532	cellular_component	small nuclear ribonucleoprotein complex
q	0034709	cellular_component	methylosome
q	0034715	cellular_component	pICln-Sm protein complex
q	0034719	cellular_component	SMN-Sm protein complex
q	0036261	biological_process	7-methylguanosine cap hypermethylation
q	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
q	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
q	0070062	cellular_component	extracellular exosome
q	0071005	cellular_component	U2-type precatalytic spliceosome
q	0071007	cellular_component	U2-type catalytic step 2 spliceosome
q	0071011	cellular_component	precatalytic spliceosome
q	0071013	cellular_component	catalytic step 2 spliceosome
q	0097525	cellular_component	spliceosomal snRNP complex
q	1903241	biological_process	U2-type prespliceosome assembly
q	1990904	cellular_component	ribonucleoprotein complex
Q	0000244	biological_process	spliceosomal tri-snRNP complex assembly
Q	0000245	biological_process	spliceosomal complex assembly
Q	0000387	biological_process	spliceosomal snRNP assembly
Q	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
Q	0000398	biological_process	mRNA splicing, via spliceosome
Q	0003723	molecular_function	RNA binding
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0005654	cellular_component	nucleoplasm
Q	0005681	cellular_component	spliceosomal complex
Q	0005682	cellular_component	U5 snRNP
Q	0005684	cellular_component	U2-type spliceosomal complex
Q	0005685	cellular_component	U1 snRNP
Q	0005686	cellular_component	U2 snRNP
Q	0005687	cellular_component	U4 snRNP
Q	0005689	cellular_component	U12-type spliceosomal complex
Q	0005829	cellular_component	cytosol
Q	0006397	biological_process	mRNA processing
Q	0008380	biological_process	RNA splicing
Q	0030532	cellular_component	small nuclear ribonucleoprotein complex
Q	0034709	cellular_component	methylosome
Q	0034715	cellular_component	pICln-Sm protein complex
Q	0034719	cellular_component	SMN-Sm protein complex
Q	0036261	biological_process	7-methylguanosine cap hypermethylation
Q	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
Q	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
Q	0070062	cellular_component	extracellular exosome
Q	0071005	cellular_component	U2-type precatalytic spliceosome
Q	0071007	cellular_component	U2-type catalytic step 2 spliceosome
Q	0071011	cellular_component	precatalytic spliceosome
Q	0071013	cellular_component	catalytic step 2 spliceosome
Q	0097525	cellular_component	spliceosomal snRNP complex
Q	1903241	biological_process	U2-type prespliceosome assembly
Q	1990904	cellular_component	ribonucleoprotein complex
r	0000243	cellular_component	commitment complex
r	0000244	biological_process	spliceosomal tri-snRNP complex assembly
r	0000245	biological_process	spliceosomal complex assembly
r	0000387	biological_process	spliceosomal snRNP assembly
r	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
r	0000398	biological_process	mRNA splicing, via spliceosome
r	0003723	molecular_function	RNA binding
r	0005515	molecular_function	protein binding
r	0005634	cellular_component	nucleus
r	0005654	cellular_component	nucleoplasm
r	0005681	cellular_component	spliceosomal complex
r	0005682	cellular_component	U5 snRNP
r	0005683	cellular_component	U7 snRNP
r	0005684	cellular_component	U2-type spliceosomal complex
r	0005685	cellular_component	U1 snRNP
r	0005686	cellular_component	U2 snRNP
r	0005687	cellular_component	U4 snRNP
r	0005689	cellular_component	U12-type spliceosomal complex
r	0005697	cellular_component	telomerase holoenzyme complex
r	0005737	cellular_component	cytoplasm
r	0005829	cellular_component	cytosol
r	0006396	biological_process	RNA processing
r	0006397	biological_process	mRNA processing
r	0006479	biological_process	protein methylation
r	0008380	biological_process	RNA splicing
r	0016604	cellular_component	nuclear body
r	0019899	molecular_function	enzyme binding
r	0030532	cellular_component	small nuclear ribonucleoprotein complex
r	0034709	cellular_component	methylosome
r	0034715	cellular_component	pICln-Sm protein complex
r	0034719	cellular_component	SMN-Sm protein complex
r	0036261	biological_process	7-methylguanosine cap hypermethylation
r	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
r	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
r	0070034	molecular_function	telomerase RNA binding
r	0071005	cellular_component	U2-type precatalytic spliceosome
r	0071007	cellular_component	U2-type catalytic step 2 spliceosome
r	0071011	cellular_component	precatalytic spliceosome
r	0071013	cellular_component	catalytic step 2 spliceosome
r	0071045	biological_process	nuclear histone mRNA catabolic process
r	0071208	molecular_function	histone pre-mRNA DCP binding
r	0071209	molecular_function	U7 snRNA binding
r	0097526	cellular_component	spliceosomal tri-snRNP complex
r	1903241	biological_process	U2-type prespliceosome assembly
r	1990904	cellular_component	ribonucleoprotein complex
R	0000243	cellular_component	commitment complex
R	0000244	biological_process	spliceosomal tri-snRNP complex assembly
R	0000245	biological_process	spliceosomal complex assembly
R	0000387	biological_process	spliceosomal snRNP assembly
R	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
R	0000398	biological_process	mRNA splicing, via spliceosome
R	0003723	molecular_function	RNA binding
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0005654	cellular_component	nucleoplasm
R	0005681	cellular_component	spliceosomal complex
R	0005682	cellular_component	U5 snRNP
R	0005683	cellular_component	U7 snRNP
R	0005684	cellular_component	U2-type spliceosomal complex
R	0005685	cellular_component	U1 snRNP
R	0005686	cellular_component	U2 snRNP
R	0005687	cellular_component	U4 snRNP
R	0005689	cellular_component	U12-type spliceosomal complex
R	0005697	cellular_component	telomerase holoenzyme complex
R	0005737	cellular_component	cytoplasm
R	0005829	cellular_component	cytosol
R	0006396	biological_process	RNA processing
R	0006397	biological_process	mRNA processing
R	0006479	biological_process	protein methylation
R	0008380	biological_process	RNA splicing
R	0016604	cellular_component	nuclear body
R	0019899	molecular_function	enzyme binding
R	0030532	cellular_component	small nuclear ribonucleoprotein complex
R	0034709	cellular_component	methylosome
R	0034715	cellular_component	pICln-Sm protein complex
R	0034719	cellular_component	SMN-Sm protein complex
R	0036261	biological_process	7-methylguanosine cap hypermethylation
R	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
R	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
R	0070034	molecular_function	telomerase RNA binding
R	0071005	cellular_component	U2-type precatalytic spliceosome
R	0071007	cellular_component	U2-type catalytic step 2 spliceosome
R	0071011	cellular_component	precatalytic spliceosome
R	0071013	cellular_component	catalytic step 2 spliceosome
R	0071045	biological_process	nuclear histone mRNA catabolic process
R	0071208	molecular_function	histone pre-mRNA DCP binding
R	0071209	molecular_function	U7 snRNA binding
R	0097526	cellular_component	spliceosomal tri-snRNP complex
R	1903241	biological_process	U2-type prespliceosome assembly
R	1990904	cellular_component	ribonucleoprotein complex
s	0000244	biological_process	spliceosomal tri-snRNP complex assembly
s	0000245	biological_process	spliceosomal complex assembly
s	0000387	biological_process	spliceosomal snRNP assembly
s	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
s	0000398	biological_process	mRNA splicing, via spliceosome
s	0003723	molecular_function	RNA binding
s	0005515	molecular_function	protein binding
s	0005634	cellular_component	nucleus
s	0005654	cellular_component	nucleoplasm
s	0005681	cellular_component	spliceosomal complex
s	0005682	cellular_component	U5 snRNP
s	0005683	cellular_component	U7 snRNP
s	0005684	cellular_component	U2-type spliceosomal complex
s	0005685	cellular_component	U1 snRNP
s	0005686	cellular_component	U2 snRNP
s	0005687	cellular_component	U4 snRNP
s	0005689	cellular_component	U12-type spliceosomal complex
s	0005697	cellular_component	telomerase holoenzyme complex
s	0005829	cellular_component	cytosol
s	0006397	biological_process	mRNA processing
s	0008380	biological_process	RNA splicing
s	0030532	cellular_component	small nuclear ribonucleoprotein complex
s	0034709	cellular_component	methylosome
s	0034715	cellular_component	pICln-Sm protein complex
s	0034719	cellular_component	SMN-Sm protein complex
s	0036261	biological_process	7-methylguanosine cap hypermethylation
s	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
s	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
s	0071005	cellular_component	U2-type precatalytic spliceosome
s	0071007	cellular_component	U2-type catalytic step 2 spliceosome
s	0071011	cellular_component	precatalytic spliceosome
s	0071013	cellular_component	catalytic step 2 spliceosome
s	0071045	biological_process	nuclear histone mRNA catabolic process
s	1903241	biological_process	U2-type prespliceosome assembly
s	1990904	cellular_component	ribonucleoprotein complex
S	0000244	biological_process	spliceosomal tri-snRNP complex assembly
S	0000245	biological_process	spliceosomal complex assembly
S	0000387	biological_process	spliceosomal snRNP assembly
S	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
S	0000398	biological_process	mRNA splicing, via spliceosome
S	0003723	molecular_function	RNA binding
S	0005515	molecular_function	protein binding
S	0005634	cellular_component	nucleus
S	0005654	cellular_component	nucleoplasm
S	0005681	cellular_component	spliceosomal complex
S	0005682	cellular_component	U5 snRNP
S	0005683	cellular_component	U7 snRNP
S	0005684	cellular_component	U2-type spliceosomal complex
S	0005685	cellular_component	U1 snRNP
S	0005686	cellular_component	U2 snRNP
S	0005687	cellular_component	U4 snRNP
S	0005689	cellular_component	U12-type spliceosomal complex
S	0005697	cellular_component	telomerase holoenzyme complex
S	0005829	cellular_component	cytosol
S	0006397	biological_process	mRNA processing
S	0008380	biological_process	RNA splicing
S	0030532	cellular_component	small nuclear ribonucleoprotein complex
S	0034709	cellular_component	methylosome
S	0034715	cellular_component	pICln-Sm protein complex
S	0034719	cellular_component	SMN-Sm protein complex
S	0036261	biological_process	7-methylguanosine cap hypermethylation
S	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
S	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
S	0071005	cellular_component	U2-type precatalytic spliceosome
S	0071007	cellular_component	U2-type catalytic step 2 spliceosome
S	0071011	cellular_component	precatalytic spliceosome
S	0071013	cellular_component	catalytic step 2 spliceosome
S	0071045	biological_process	nuclear histone mRNA catabolic process
S	1903241	biological_process	U2-type prespliceosome assembly
S	1990904	cellular_component	ribonucleoprotein complex
t	0000244	biological_process	spliceosomal tri-snRNP complex assembly
t	0000245	biological_process	spliceosomal complex assembly
t	0000387	biological_process	spliceosomal snRNP assembly
t	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
t	0000398	biological_process	mRNA splicing, via spliceosome
t	0003723	molecular_function	RNA binding
t	0005515	molecular_function	protein binding
t	0005634	cellular_component	nucleus
t	0005654	cellular_component	nucleoplasm
t	0005681	cellular_component	spliceosomal complex
t	0005683	cellular_component	U7 snRNP
t	0005684	cellular_component	U2-type spliceosomal complex
t	0005685	cellular_component	U1 snRNP
t	0005687	cellular_component	U4 snRNP
t	0005689	cellular_component	U12-type spliceosomal complex
t	0005829	cellular_component	cytosol
t	0006397	biological_process	mRNA processing
t	0008380	biological_process	RNA splicing
t	0022618	biological_process	protein-RNA complex assembly
t	0030532	cellular_component	small nuclear ribonucleoprotein complex
t	0034709	cellular_component	methylosome
t	0034715	cellular_component	pICln-Sm protein complex
t	0034719	cellular_component	SMN-Sm protein complex
t	0036261	biological_process	7-methylguanosine cap hypermethylation
t	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
t	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
t	0071005	cellular_component	U2-type precatalytic spliceosome
t	0071007	cellular_component	U2-type catalytic step 2 spliceosome
t	0071013	cellular_component	catalytic step 2 spliceosome
t	0071045	biological_process	nuclear histone mRNA catabolic process
t	1903241	biological_process	U2-type prespliceosome assembly
t	1990904	cellular_component	ribonucleoprotein complex
T	0000244	biological_process	spliceosomal tri-snRNP complex assembly
T	0000245	biological_process	spliceosomal complex assembly
T	0000387	biological_process	spliceosomal snRNP assembly
T	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
T	0000398	biological_process	mRNA splicing, via spliceosome
T	0003723	molecular_function	RNA binding
T	0005515	molecular_function	protein binding
T	0005634	cellular_component	nucleus
T	0005654	cellular_component	nucleoplasm
T	0005681	cellular_component	spliceosomal complex
T	0005683	cellular_component	U7 snRNP
T	0005684	cellular_component	U2-type spliceosomal complex
T	0005685	cellular_component	U1 snRNP
T	0005687	cellular_component	U4 snRNP
T	0005689	cellular_component	U12-type spliceosomal complex
T	0005829	cellular_component	cytosol
T	0006397	biological_process	mRNA processing
T	0008380	biological_process	RNA splicing
T	0022618	biological_process	protein-RNA complex assembly
T	0030532	cellular_component	small nuclear ribonucleoprotein complex
T	0034709	cellular_component	methylosome
T	0034715	cellular_component	pICln-Sm protein complex
T	0034719	cellular_component	SMN-Sm protein complex
T	0036261	biological_process	7-methylguanosine cap hypermethylation
T	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
T	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
T	0071005	cellular_component	U2-type precatalytic spliceosome
T	0071007	cellular_component	U2-type catalytic step 2 spliceosome
T	0071013	cellular_component	catalytic step 2 spliceosome
T	0071045	biological_process	nuclear histone mRNA catabolic process
T	1903241	biological_process	U2-type prespliceosome assembly
T	1990904	cellular_component	ribonucleoprotein complex
u	0000244	biological_process	spliceosomal tri-snRNP complex assembly
u	0000245	biological_process	spliceosomal complex assembly
u	0000387	biological_process	spliceosomal snRNP assembly
u	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
u	0000398	biological_process	mRNA splicing, via spliceosome
u	0003723	molecular_function	RNA binding
u	0005515	molecular_function	protein binding
u	0005634	cellular_component	nucleus
u	0005654	cellular_component	nucleoplasm
u	0005681	cellular_component	spliceosomal complex
u	0005682	cellular_component	U5 snRNP
u	0005683	cellular_component	U7 snRNP
u	0005684	cellular_component	U2-type spliceosomal complex
u	0005685	cellular_component	U1 snRNP
u	0005686	cellular_component	U2 snRNP
u	0005687	cellular_component	U4 snRNP
u	0005689	cellular_component	U12-type spliceosomal complex
u	0005829	cellular_component	cytosol
u	0006397	biological_process	mRNA processing
u	0008380	biological_process	RNA splicing
u	0030532	cellular_component	small nuclear ribonucleoprotein complex
u	0034709	cellular_component	methylosome
u	0034719	cellular_component	SMN-Sm protein complex
u	0036261	biological_process	7-methylguanosine cap hypermethylation
u	0043186	cellular_component	P granule
u	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
u	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
u	0071004	cellular_component	U2-type prespliceosome
u	0071005	cellular_component	U2-type precatalytic spliceosome
u	0071007	cellular_component	U2-type catalytic step 2 spliceosome
u	0071011	cellular_component	precatalytic spliceosome
u	0071013	cellular_component	catalytic step 2 spliceosome
u	0071045	biological_process	nuclear histone mRNA catabolic process
u	0097526	cellular_component	spliceosomal tri-snRNP complex
u	1903241	biological_process	U2-type prespliceosome assembly
u	1990904	cellular_component	ribonucleoprotein complex
U	0000244	biological_process	spliceosomal tri-snRNP complex assembly
U	0000245	biological_process	spliceosomal complex assembly
U	0000387	biological_process	spliceosomal snRNP assembly
U	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
U	0000398	biological_process	mRNA splicing, via spliceosome
U	0003723	molecular_function	RNA binding
U	0005515	molecular_function	protein binding
U	0005634	cellular_component	nucleus
U	0005654	cellular_component	nucleoplasm
U	0005681	cellular_component	spliceosomal complex
U	0005682	cellular_component	U5 snRNP
U	0005683	cellular_component	U7 snRNP
U	0005684	cellular_component	U2-type spliceosomal complex
U	0005685	cellular_component	U1 snRNP
U	0005686	cellular_component	U2 snRNP
U	0005687	cellular_component	U4 snRNP
U	0005689	cellular_component	U12-type spliceosomal complex
U	0005829	cellular_component	cytosol
U	0006397	biological_process	mRNA processing
U	0008380	biological_process	RNA splicing
U	0030532	cellular_component	small nuclear ribonucleoprotein complex
U	0034709	cellular_component	methylosome
U	0034719	cellular_component	SMN-Sm protein complex
U	0036261	biological_process	7-methylguanosine cap hypermethylation
U	0043186	cellular_component	P granule
U	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
U	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
U	0071004	cellular_component	U2-type prespliceosome
U	0071005	cellular_component	U2-type precatalytic spliceosome
U	0071007	cellular_component	U2-type catalytic step 2 spliceosome
U	0071011	cellular_component	precatalytic spliceosome
U	0071013	cellular_component	catalytic step 2 spliceosome
U	0071045	biological_process	nuclear histone mRNA catabolic process
U	0097526	cellular_component	spliceosomal tri-snRNP complex
U	1903241	biological_process	U2-type prespliceosome assembly
U	1990904	cellular_component	ribonucleoprotein complex
V	0000244	biological_process	spliceosomal tri-snRNP complex assembly
V	0000245	biological_process	spliceosomal complex assembly
V	0000387	biological_process	spliceosomal snRNP assembly
V	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
V	0000398	biological_process	mRNA splicing, via spliceosome
V	0004843	molecular_function	cysteine-type deubiquitinase activity
V	0005515	molecular_function	protein binding
V	0005634	cellular_component	nucleus
V	0005654	cellular_component	nucleoplasm
V	0005681	cellular_component	spliceosomal complex
V	0006397	biological_process	mRNA processing
V	0008270	molecular_function	zinc ion binding
V	0008380	biological_process	RNA splicing
V	0016579	biological_process	protein deubiquitination
V	0016787	molecular_function	hydrolase activity
V	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
V	0046872	molecular_function	metal ion binding
V	0051301	biological_process	cell division

Functional Information from PROSITE/UniProt

site_id	PS01082
Number of Residues	18
Details	RIBOSOMAL_L7AE Ribosomal protein L7Ae signature. CedknVPYvfVrSKqaLG

Chain	Residue	Details
I	CYS73-GLY90

---

site_id	PS00436
Number of Residues	12
Details	PEROXIDASE_2 Peroxidases active site signature. TVrvARVmWHPS

Chain	Residue	Details
L	THR323-SER334

---

site_id	PS00039
Number of Residues	9
Details	DEAD_ATP_HELICASE DEAD-box subfamily ATP-dependent helicases signature. VLDEADRmI

Chain	Residue	Details
F	VAL547-ILE555

---

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LGTTcyDrSWRLWDL

Chain	Residue	Details
L	LEU338-LEU352
L	ILE422-LEU436
D	LEU81-VAL95
D	LEU124-SER138
D	VAL167-ILE181
D	ILE208-LEU222
D	ILE300-THR314

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	78
Details	Repeat: {"description":"WD 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	86
Details	Repeat: {"description":"WD 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	79
Details	Repeat: {"description":"WD 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	78
Details	Repeat: {"description":"WD 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	78
Details	Repeat: {"description":"WD 5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	79
Details	Repeat: {"description":"WD 6"}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	63
Details	Repeat: {"description":"WD 7"}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"25755297","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	183
Details	Domain: {"description":"Helicase ATP-binding 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	237
Details	Domain: {"description":"Helicase C-terminal 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00542","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	305
Details	Domain: {"description":"SEC63 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	175
Details	Domain: {"description":"Helicase ATP-binding 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	208
Details	Domain: {"description":"Helicase C-terminal 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00542","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	3
Details	Motif: {"description":"DEIH box"}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	3
Details	Motif: {"description":"DEVH box"}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23045696","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4F93","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"F1LNJ2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	3
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q6P4T2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	131
Details	Domain: {"description":"MPN","evidences":[{"source":"PROSITE-ProRule","id":"PRU01182","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI24
Number of Residues	491
Details	Region: {"description":"Reverse transcriptase homology domain"}

Chain

Residue

Details

---

site_id	SWS_FT_FI25
Number of Residues	273
Details	Region: {"description":"Linker"}

Chain

Residue

Details

---

site_id	SWS_FT_FI26
Number of Residues	13
Details	Region: {"description":"Important for branch point selection","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI27
Number of Residues	171
Details	Region: {"description":"Restriction endonuclease homology domain"}

Chain

Residue

Details

---

site_id	SWS_FT_FI28
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI29
Number of Residues	1
Details	Modified residue: {"description":"N6,N6-dimethyllysine","evidences":[{"source":"PubMed","id":"24129315","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI30
Number of Residues	28
Details	Motif: {"description":"Q motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU00552","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI31
Number of Residues	3
Details	Motif: {"description":"DEAD box","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI32
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI33
Number of Residues	8
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI34
Number of Residues	282
Details	Domain: {"description":"tr-type G","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI35
Number of Residues	14
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI36
Number of Residues	727
Details	Domain: {"description":"Sm","evidences":[{"source":"PROSITE-ProRule","id":"PRU01346","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI37
Number of Residues	1
Details	Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUL-2007","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Matallanas D.","Cooper W.N.","Kolch W."]}}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI38
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"17525332","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI39
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17081983","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18318008","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI41
Number of Residues	69
Details	Coiled coil: {"evidences":[{"source":"PubMed","id":"17412961","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI42
Number of Residues	1
Details	Site: {"description":"Interaction with U4 snRNA","evidences":[{"source":"PubMed","id":"17412961","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI43
Number of Residues	3
Details	Site: {"description":"Interaction with U4 snRNA and U4atac snRNA","evidences":[{"source":"PubMed","id":"17412961","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI44
Number of Residues	1
Details	Site: {"description":"Interaction with U4atac snRNA","evidences":[{"source":"PubMed","id":"17412961","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI45
Number of Residues	12
Details	Region: {"description":"Interaction with U4 snRNA and U4atac snRNA","evidences":[{"source":"PubMed","id":"17412961","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21784869","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI46
Number of Residues	32
Details	Region: {"description":"Important for U4 snRNA-binding","evidences":[{"source":"PubMed","id":"10545122","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI47
Number of Residues	2
Details	Site: {"description":"Interaction with U4 snRNA and U4atac snRNA","evidences":[{"source":"PubMed","id":"17412961","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21784869","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI48
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9D0T1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI49
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00502","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---