3JC7
Structure of the eukaryotic replicative CMG helicase and pumpjack motion
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (2) | DNA replication licensing factor MCM2 | polymer | 868 | 98911.5 | 1 | UniProt (P29469) Pfam (PF12619) Pfam (PF14551) Pfam (PF17207) Pfam (PF00493) Pfam (PF17855) | Saccharomyces cerevisiae (yeast) | Minichromosome maintenance protein 2 |
| 2 | B (3) | DNA replication licensing factor MCM3 | polymer | 971 | 107653.5 | 1 | UniProt (P24279) Pfam (PF22207) Pfam (PF23191) Pfam (PF14551) Pfam (PF17207) Pfam (PF00493) Pfam (PF17855) | Saccharomyces cerevisiae (yeast) | Minichromosome maintenance protein 3 |
| 3 | C (4) | DNA replication licensing factor MCM4 | polymer | 933 | 105138.4 | 1 | UniProt (P30665) Pfam (PF14551) Pfam (PF17207) Pfam (PF00493) Pfam (PF17855) Pfam (PF21128) | Saccharomyces cerevisiae (yeast) | Cell division control protein 54 |
| 4 | D (5) | Minichromosome maintenance protein 5 | polymer | 775 | 86505.7 | 1 | UniProt (P29496) Pfam (PF14551) Pfam (PF17207) Pfam (PF00493) Pfam (PF17855) Pfam (PF21933) | Saccharomyces cerevisiae (yeast) | Cell division control protein 46 |
| 5 | E (6) | DNA replication licensing factor MCM6 | polymer | 1017 | 113110.2 | 1 | UniProt (P53091) Pfam (PF14551) Pfam (PF17207) Pfam (PF00493) Pfam (PF17855) Pfam (PF18263) | Saccharomyces cerevisiae (yeast) | Minichromosome maintenance protein 6 |
| 6 | F (7) | DNA replication licensing factor MCM7 | polymer | 845 | 95049.9 | 1 | UniProt (P38132) Pfam (PF14551) Pfam (PF17207) Pfam (PF00493) Pfam (PF17855) Pfam (PF24901) | Saccharomyces cerevisiae (yeast) | Cell division control protein 47, Minichromosome maintenance protein 7 |
| 7 | G (c) | Cell division control protein 45 | polymer | 650 | 74173.6 | 1 | UniProt (Q08032) Pfam (PF02724) | Saccharomyces cerevisiae (yeast) | |
| 8 | H (D) | DNA replication complex GINS protein SLD5 | polymer | 294 | 33983.6 | 1 | UniProt (Q03406) Pfam (PF05916) Pfam (PF16922) | Saccharomyces cerevisiae (yeast) | |
| 9 | I (B) | DNA replication complex GINS protein PSF2 | polymer | 213 | 25096.8 | 1 | UniProt (P40359) Pfam (PF25005) Pfam (PF05916) | Saccharomyces cerevisiae (yeast) | Partner of Sld five 2 |
| 10 | J (A) | DNA replication complex GINS protein PSF1 | polymer | 208 | 24157.4 | 1 | UniProt (Q12488) Pfam (PF05916) Pfam (PF24997) | Saccharomyces cerevisiae (yeast) | Partner of Sld five 1 |
| 11 | K (C) | DNA replication complex GINS protein PSF3 | polymer | 194 | 21977.1 | 1 | UniProt (Q12146) Pfam (PF22466) Pfam (PF05916) | Saccharomyces cerevisiae (yeast) | Partner of Sld five 3 |
| 12 | L (7) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) |
Sequence modifications
c: 1 - 650 (UniProt: Q08032)
A: 1 - 208 (UniProt: Q12488)
| PDB | External Database | Details |
|---|---|---|
| Ala 22 | His 22 | conflict |
| Glu 155 | Gln 155 | conflict |
| Thr 551 | Trp 551 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Ala 161 | Val 161 | conflict |
| Gln 192 | Arg 192 | conflict |
| Leu 207 | Lys 207 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 11 |
| Total formula weight | 785757.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 65.4 | |
| All* | Total formula weight | 785823.3 |
