3JBT

Atomic structure of the Apaf-1 apoptosome

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C, E, G, I... (A, C, E, G, I...)	Apoptotic protease-activating factor 1	polymer	1260	143647.3	7	UniProt (O14727) Pfam (PF00619) Pfam (PF00400) Pfam (PF00931) Pfam (PF21296) Pfam (PF17908)	Homo sapiens (human)	APAF-1
2	B, D, F, H, J... (B, D, F, H, J...)	Cytochrome c	polymer	105	11856.8	7	UniProt (P00004) Pfam (PF00034)	Equus caballus (horse)
3	AA, DA, GA, O, R... (I, K, M, A, C...)	2'-DEOXYADENOSINE 5'-TRIPHOSPHATE	non-polymer		491.2	7	Chemie (DTP)
4	BA, EA, HA, P, S... (I, K, M, A, C...)	MAGNESIUM ION	non-polymer		24.3	7	Chemie (MG)
5	CA, FA, IA, Q, T... (J, L, N, B, D...)	PROTOPORPHYRIN IX CONTAINING FE	non-polymer		616.5	7	Chemie (HEM)

Sequence modifications

A, C, E, G, I, K, M: 1 - 1248 (UniProt: O14727)

PDB	External Database	Details
Leu 1249	-	expression tag
Glu 1250	-	expression tag
His 1251	-	expression tag
His 1252	-	expression tag
His 1253	-	expression tag
His 1254	-	expression tag
His 1255	-	expression tag
His 1256	-	expression tag
His 1257	-	expression tag
His 1258	-	expression tag
His 1259	-	expression tag
His 1260	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	14
	Total formula weight	1088529.0
Non-Polymers*	Number of molecules	21
	Total formula weight	7923.8
All*	Total formula weight	1096452.8

*Water molecules are not included.