3JBR
Cryo-EM structure of the rabbit voltage-gated calcium channel Cav1.1 complex at 4.2 angstrom
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Voltage-dependent L-type calcium channel subunit alpha-1S | polymer | 1873 | 208655.9 | 1 | UniProt (P07293) Pfam (PF00520) Pfam (PF08016) Pfam (PF16905) Pfam (PF08763) Pfam (PF16885) | Oryctolagus cuniculus (European rabbit Japanese white rabbit domestic rabbit rabbits) | Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle, Voltage-gated calcium channel subunit alpha Cav1.1 |
| 2 | B (B) | Voltage-dependent L-type calcium channel subunit beta-2 | polymer | 356 | 40300.0 | 1 | UniProt (Q8VGC3) Pfam (PF12052) Pfam (PF00625) | Rattus norvegicus (rat) | CAB2, Calcium channel voltage-dependent subunit beta 2' |
| 3 | C (E) | Voltage-dependent calcium channel gamma-1 subunit | polymer | 222 | 25082.3 | 1 | UniProt (P19518) Pfam (PF13903) | Oryctolagus cuniculus (European rabbit Japanese white rabbit domestic rabbit rabbits) | Dihydropyridine-sensitive L-type, skeletal muscle calcium channel subunit gamma |
| 4 | D (F) | Voltage-dependent calcium channel subunit alpha-2/delta-1 | polymer | 1106 | 116775.6 | 1 | UniProt (P13806) Pfam (PF08399) Pfam (PF00092) Pfam (PF08473) | Oryctolagus cuniculus (European rabbit Japanese white rabbit domestic rabbit rabbits) | Voltage-gated calcium channel subunit alpha-2/delta-1, Voltage-dependent calcium channel subunit alpha-2-1, Voltage-dependent calcium channel subunit delta-1 |
| 5 | E (A) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 6 | F, G, H, I, J... (F) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 15 | Chemie (NAG) | |||
| 7 | U, V (F) | beta-D-mannopyranose | non-polymer | 180.2 | 2 | Chemie (BMA) |
Sequence modifications
A: 1 - 1395 (UniProt: P07293)
A: 1396 - 1520 (PDB: 3JBR)
A: 1521 - 1873 (UniProt: P07293)
B: 17 - 200 (UniProt: Q8VGC3)
B: 202 - 424 (UniProt: Q8VGC3)
F: 1 - 39 (UniProt: P13806)
F: 40 - 55 (PDB: 3JBR)
F: 56 - 661 (UniProt: P13806)
F: 662 - 955 (PDB: 3JBR)
F: 956 - 1106 (UniProt: P13806)
A: 1396 - 1520 (PDB: 3JBR)
A: 1521 - 1873 (UniProt: P07293)
B: 17 - 200 (UniProt: Q8VGC3)
| PDB | External Database | Details |
|---|---|---|
| Gly 14 | - | expression tag |
| His 15 | - | expression tag |
| Met 16 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met 201 | - | linker |
F: 40 - 55 (PDB: 3JBR)
F: 56 - 661 (UniProt: P13806)
F: 662 - 955 (PDB: 3JBR)
F: 956 - 1106 (UniProt: P13806)
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 390813.7 | |
| Non-Polymers* | Number of molecules | 18 |
| Total formula weight | 3718.5 | |
| All* | Total formula weight | 394532.2 |
